Association of Gender-Affirming Hormone Therapy With Depression, Thoughts of Suicide, and Attempted Suicide Among Transgender and Nonbinary Youth
Association of Gender-Affirming Hormone Therapy With Depression, Thoughts of Suicide, and Attempted Suicide Among Transgender and Nonbinary Youth
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DOI：
10.1016/j.jadohealth.2021.10.036
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发表时间：
2022-03-16
影响因子：
7.6
通讯作者：
Davis, Carrie K.
中科院分区：
文献类型：
--
作者：
Green, Amy E.;DeChants, Jonah P.;Davis, Carrie K.
目的：目前尚无大规模研究调查接受性别肯定激素治疗(GAHT)的跨性别者和非双性恋者的心理健康状况。这项研究的目的是在大样本的变性人和非双性恋者青年中检查GAHT与抑郁、自杀念头和自杀未遂之间的关系。方法：作为2020年调查的一部分，收集了34,759名13-24岁的女同性恋者、男同性恋者、双性恋者、变性人、同性恋者和有问题的年轻人的数据，其中包括11,914名变性人或非双性恋青年。调整后的Logistic回归分析评估了在那些想要接受GAHT治疗的患者中，接受GAHT治疗是否与较低水平的抑郁、自杀念头和自杀未遂有关。结果：一半的跨性别者和非双性恋者表示他们没有使用GAHT，但愿意使用，36%的人对接受GAHT不感兴趣，14%的人正在接受GAHT。父母对孩子性别认同的支持与接受GAHT有很强的关系，近80%接受GAHT的人报告说，他们至少有一位父母支持他们的性别认同。与那些想要GAHT但没有接受治疗的人相比，使用GAHT与最近抑郁(调整后的优势比[AOR]=.73，p<；.001)和严重考虑自杀(AOR=.74，p<；.001)的几率较低相关。对于18岁以下的年轻人，GAHT与近期抑郁(AOR=.61，p<；.01)和过去一年自杀未遂(AOR=.62，p<；.05)的几率较低相关。结论：研究结果支持在跨性别者和非双性恋者中接受GAHT治疗与较低的抑郁和自杀率之间的关系。(C)2021年青少年健康与医学学会。由爱思唯尔公司出版。这是CC BY-NC-ND许可证(http://creativecommons.org/licenses/by-nc-nd/4.0/).下的一篇开放获取文章
Purpose: There are no large-scale studies examining mental health among transgender and nonbinary youth who receive gender-affirming hormone therapy (GAHT). The purpose of this study is to examine associations among access to GAHT with depression, thoughts of suicide, and attempted suicide among a large sample of transgender and nonbinary youth. Methods: Data were collected as part of a 2020 survey of 34,759 lesbian, gay, bisexual, transgender, queer, and questioning youth aged 13-24, including 11,914 transgender or nonbinary youth. Adjusted logistic regression assessed whether receipt of GAHT was associated with lower levels of depression, thoughts of suicide, and attempted suicide among those who wanted to receive GAHT. Results: Half of transgender and nonbinary youth said they were not using GAHT but would like to, 36% were not interested in receiving GAHT, and 14% were receiving GAHT. Parent support for their child's gender identity had a strong relationship with receipt of GAHT, with nearly 80% of those who received GAHT reporting they had at least one parent who supported their gender identity. Use of GAHT was associated with lower odds of recent depression (adjusted odds ratio [aOR] = .73, p < .001) and seriously considering suicide (aOR = .74, p < .001) compared to those who wanted GAHT but did not receive it. For youth under age 18, GAHT was associated with lower odds of recent depression (aOR = .61, p < .01) and of a past-year suicide attempt (aOR = .62, p < .05). Conclusions: Findings support a relationship between access to GAHT and lower rates of depression and suicidality among transgender and nonbinary youth. (c) 2021 Society for Adolescent Health and Medicine. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).