Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system.
Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system.
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DOI：
10.1364/boe.7.004275
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发表时间：
2016-10-01
影响因子：
3.4
通讯作者：
Everdell NL
中科院分区：
文献类型：
--
作者：
Chitnis D;Cooper RJ;Dempsey L;Powell S;Quaggia S;Highton D;Elwell C;Hebden JC;Everdell NL
我们提出了第一个三维的，功能性的图像，人类大脑获得使用无纤维，高密度扩散光学断层扫描系统。我们的技术由独立的、小型化的、硅胶封装的DOT模块组成，可以直接放置在头皮上。其中四个模块可在约60 × 65 mm2的头皮面积上提供多达128个双波长测量通道。使用一系列的运动皮层刺激实验，我们证明，该系统可以获得高品质的，连续波测量源检测器的分离范围从14到55毫米的成人，在存在的头发。我们确定了强大的血液动力学反应功能，在5个科目，并提出了弥漫性光学断层扫描图像，描绘功能性血液动力学反应，以及本地化在所有三个方面的个人和组的水平。该原型模块化系统为新一代可穿戴、无线、高密度光学神经成像技术铺平了道路。
We present the first three-dimensional, functional images of the human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone-encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dual-wavelength measurement channels over a scalp area of approximately 60 × 65 mm2. Using a series of motor-cortex stimulation experiments, we demonstrate that this system can obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well-localized in all three dimensions at both the individual and group levels. This prototype modular system paves the way for a new generation of wearable, wireless, high-density optical neuroimaging technologies.