Molecular and biological properties of a neural cell adhesion molecule.
Molecular and biological properties of a neural cell adhesion molecule.
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神经细胞粘附分子的分子和生物学特性。
DOI：
10.1101/sqb.1983.048.01.055
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Rutishauser,U
中科院分区：
文献类型：
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作者：
Rutishauser,U
细胞-细胞粘附是复杂生物体发育过程中最基本的事件之一。除了简单地将某些细胞结合在一起外，这种相互作用被认为可以诱导分化，并可能整合来自各种来源的信息以产生特定的组织模式。特别强调的是在神经系统发育过程中细胞-细胞识别的作用。这种兴趣很大程度上源于这样一个事实，即神经组织的结构极其复杂和多样，其功能取决于这种结构的细节。对细胞间相互作用进行有意义的分析需要对它们的化学性质和生物学后果进行精确的描述。试图识别参与细胞-细胞结合的分子包括对凝集素样凝集素、促进或抑制聚集因子和粘附所需的细胞表面抗原的描述（回顾，见Frazier和Glaser 1979）。其中一条研究路线导致了对一种叫做N-CAM的特殊细胞粘附分子的广泛研究，这种分子的功能主要与神经元细胞之间的粘附有关。与许多其他研究相比，N-CAM已被纯化和表征，显示出具有特定的细胞结合活性，并且已知直接参与对神经元发育至关重要的各种粘附过程。因此，它代表了具有特定和确定的发育功能的细胞表面分子的首次成功描述之一。
Cell-cell adhesions are among the most fundamental events in the development of complex organisms. In addition to simply holding certain cells together, such interactions are believed to induce differentiation and potentially can integrate information from a variety of sources to produce specific tissue patterns. Particular emphasis has been placed on the role of cell-cell recognition during development of the nervous system. This interest derives largely from the fact that nerve tissue is exceedingly complex and diverse in its structure and that its function depends on the details of this architecture.A meaningful analysis of cell-cell interactions requires a precise description of both their chemical nature and biological consequences. Attempts to identify the molecules involved in cell-cell binding have included descriptions of lectinlike agglntinins, aggregation-promoting or-inhibiting factors, and cell-surface antigens required for adhesion (for review, see Frazier and Glaser 1979). One line of investigation has led to extensive work on a particular cell adhesion molecule, called N-CAM, whose function is primarily associated with adhesion among neuronal cells. In contrast with many other studies, N-CAM has been purified and characterized, shown to have specific cellbinding activity, and is known to participate directly in a variety of adhesion processes that are essential for neuronal development. It therefore represents one of the first successful descriptions of a cell-surface molecule with a specific and defined developmental function.