Development of Copper Deficiency in Rats Fed Fructose or Starch: Weekly Measurements of Copper Indices in Blood
Development of Copper Deficiency in Rats Fed Fructose or Starch: Weekly Measurements of Copper Indices in Blood
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喂食果糖或淀粉的大鼠铜缺乏症的发展：每周测量血液中的铜指数
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
S. Reiser
中科院分区：
文献类型：
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作者：
M. Fields;J. Holbrook;D. Scholfield;A. Rose;J. C. Smith;S. Reiser
用以淀粉或果糖为唯一碳水化合物来源的饲料喂养断乳大鼠7周，诱导铜缺乏。常规参数的铜状态，血浆铜浓度，铜蓝蛋白活性，红细胞超氧化物歧化酶（SOD）的活性进行了纵向监测，每周以下的发展不足，并将这些指数与严重程度的不足。虽然30%的大鼠喂养的铜缺乏果糖饮食死亡，没有死亡发生在大鼠喂养的铜缺乏淀粉饮食，血浆铜，血浆铜蓝蛋白和SOD活性降低到类似的程度，在所有大鼠喂养的铜缺乏饮食，无论类型的饮食碳水化合物。因此，没有一个指标准确地反映了更大程度的缺乏或死亡率的大鼠喂养的果糖饮食缺乏铜。本研究的结果强调了需要更敏感的测试或替代参数来评估活体动物的铜状态。
Abstract Copper deficiency was induced in weanling rats fed diets whose sole source of carbohydrates was starch or fructose for 7 weeks. Conventional parameters of copper status, plasma copper concentrations, ceruloplasmin activity, and erythrocyte superoxide dismutase (SOD) activity-were longitudinally monitored weekly to follow the development of the deficiency and to correlate these indices with the degree of severity of the deficiency. Although 30% of the rats fed a copper-deficient fructose diet died and no deaths occurred in rats fed the copper-deficient starch diet, plasma copper, ceruloplasmin, and SOD activities were reduced to a similar extent in all rats fed copper-deficient diets regardless of the type of dietary carbohydrate. Thus, none of the indices used accurately reflected the greater degree of deficiency or mortality in rats fed the fructose diet deficient in copper. The results of the present study underscore the need for more sensitive tests or alternative parameters to assess copper status in living animals.