Chemical reactions of the nitrogen mustard gases.
Chemical reactions of the nitrogen mustard gases.
复制标题
氮芥气的化学反应。
DOI：
10.1021/jo01175a021
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发表时间：
1946
期刊：
影响因子：
--
通讯作者：
M. Bergmann
中科院分区：
文献类型：
--
作者：
C. Golumbic;J. Fruton;M. Bergmann
在 MBA 系列中，已发现 1-甲基-1-(0-氯乙基)乙烯铵苦基磺酸盐 (2) 与吡啶发生类似类型的缩合反应，形成甲基-0-氯乙基-β-吡啶甲乙胺 (III)。与烟酸形成类似的3-羧基吡啶鎓衍生物(IV)。用硫二甘醇N-甲基-N-0-氯乙基-N-ß-[N'-双(0-羟乙基)锍]乙胺(V)得到。亚铵化合物还与甲基二乙醇胺反应生成N-甲基-N-0-氯乙基-N-β-[N'-甲基-N'-双(0-羟乙基)铵]乙胺(VI)，并与六亚甲基四胺反应生成六亚甲基四胺衍生物(VII)。古林和同事
In the MBA series, l-methyl-l-(0-chloroethyl) ethylenimonium picrylsul-fonate (2) has been found to undergo a similar type ofcondensation with pyridine to form methyl-0-chloroethyl-jS-pyridiniumethyIamine (III). With nicotinic acid the analogous 3-carboxypyridinium derivative (IV) is formed. With thiodiglycol N-methyl-N-0-chloroethyl-N-ß-[N'-bis (0-hydroxyethyl) sulfonium] ethylamine (V) is obtained. The imonium compound also reacts with methyl-diethanolamine to form N-methyl-N-0-chloroethyl-N-ß-[N'-methyl-N'-bis (0-hy-droxyethyl) ammonium] ethylamine (VI), and with hexamethylene tetramine to yield the hexamethylene tetraminium derivative (VII). Gurin and co-workers