Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study.
Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study.
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童年时期的欺凌行为预示着中年的炎症和肥胖：一项为期五年的出生队列研究。
DOI：
10.1017/s0033291715000653
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Louise Arseneault.
中科院分区：
文献类型：
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作者：
Ryu Takizawa;Andrea Danese;Barbara Maughan;Louise Arseneault.
BackgroundWe的目的是测试是否儿童欺凌受害增加年龄相关疾病的风险，在中年使用生物标志物，包括炎症和肥胖，独立于其他儿童的危险因素和关键的成人variables.MethodThe本研究是一个50年的前瞻性纵向出生队列研究，所有出生在英国在1958年的1周。当参与者年龄在7岁和11岁时，对欺凌的暴露进行了前瞻性评估（27.7%偶尔被欺凌; 14.6%经常被欺凌）。血液炎症生物标志物[C-反应蛋白（CRP）和纤维蛋白原]和肥胖[身体质量指数（BMI）和腰臀比]在年龄45 years.ResultsParticipants谁曾在童年经常欺负显示CRP水平增加，在中年[β = 0.07，95%置信区间（CI）0.04-0.10]和临床相关的炎症截止风险较高[CRP > 3毫克/升：20.4%对15.9%，比值比（OR）= 1.35，95%CI 1.12-1.64]。儿童期受欺负的女性的BMI高于未受欺负的参与者，肥胖风险增加（BMI ≥ 30 kg/m2：偶尔受欺负：26.0% v. 19.4%，OR = 1.45，95% CI 1.18-1.77;经常受欺负：26.2% v. 19.4%，OR = 1.41，95% CI 1.09-1.83）。调查结果仍然显着控制儿童期的风险因素（如父母的社会阶层，参与者的体重指数和精神病理学在儿童期）和关键的成人变量（如成人社会阶层，吸烟，饮食和运动）。鉴于儿童时期欺凌受害者的高发率，在生命早期处理这种形式的心理社会压力有可能减少与年龄有关的疾病及其相关负担的风险。
BackgroundWe aimed to test whether childhood bullying victimization increases risk for age-related disease at mid-life using biological markers including inflammation and adiposity, independent of other childhood risk factors and key adult variables.MethodThe present study was a 50-year prospective longitudinal birth cohort study of all births in Britain in 1 week in 1958. Exposure to bullying was assessed prospectively when participants were aged 7 and 11 years (27.7% occasionally bullied; 14.6% frequently bullied). Blood inflammation biomarkers [C-reactive protein (CRP) and fibrinogen] and adiposity [body mass index (BMI) and waist:hip ratio] were measured at age 45 years.ResultsParticipants who had been frequently bullied in childhood showed increased levels of CRP at mid-life [β = 0.07, 95% confidence interval (CI) 0.04–0.10] and higher risk for clinically relevant inflammation cut-off [CRP > 3 mg/l: 20.4% v. 15.9%, odds ratio (OR) = 1.35, 95% CI 1.12–1.64]. Women who were bullied in childhood had higher BMI than non-bullied participants and were at increased risk of being obese (BMI ≥ 30 kg/m2: occasionally bullied: 26.0% v. 19.4%, OR = 1.45, 95% CI 1.18–1.77; frequently bullied: 26.2% v. 19.4%, OR = 1.41, 95% CI 1.09–1.83). Findings remained significant when controlling for childhood risk factors (e.g. parental social class; participants’ BMI and psychopathology in childhood) and key adult variables (e.g. adult social class, smoking, diet and exercise).ConclusionsBullied children show increases in risk factors for age-related disease in middle adulthood, independent of co-occurring childhood and adult risks. Given the high prevalence of bullying victimization in childhood, tackling this form of psychosocial stress early in life has the potential of reducing risk for age-related disease and its associated burden.