Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues
Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues
复制标题
DOI：
10.1007/s10856-007-3255-7
复制
发表时间：
2008-03-01
影响因子：
3.7
通讯作者：
Osada, Yoshihito
中科院分区：
文献类型：
--
作者：
Tanabe, Yoshie;Yasuda, Kazunori;Osada, Yoshihito
本研究根据国际指南，采用植入试验评价了四种新型双网络凝胶在肌肉和皮下组织中的生物学反应。植入试验表明，尽管聚（2-丙烯酰胺-2-甲基-丙磺酸）/聚（N，N ′-二甲基丙烯酰胺）（PAMPS/PDMAAm）凝胶在1周时引起轻度炎症，但炎症程度在4周和6周时显著降低到与阴性对照相同的程度。该凝胶具有作为人工软骨应用的潜力。此外，纤维素/明胶凝胶在1周时显示出与阴性对照相同的炎症程度，然后在4周和6周时显示出逐渐可吸收的性质。该凝胶具有作为可吸收植入物应用的潜力。PAMPS/聚丙烯酰胺和纤维素/PDMAAm凝胶在每周诱导显著的炎症。在目前的情况下，这些DN凝胶很难作为临床植入物应用。
The study evaluated biological reaction of four types of novel double network gels in muscle and subcutaneous tissues, using implantation tests according to the international guideline. The implantation tests demonstrated that, although poly (2-acrylamide-2-metyl-propane sulfonic acid)/poly (N,N'-dimetyl acrylamide) (PAMPS/PDMAAm) gel induced a mild inflammation at 1 week, the degree of the inflammation significantly decreased into the same degree as that of the negative control at 4 and 6 weeks. This gel has a potential to be applied as artificial cartilage. In addition, Cellulose/Gelatin gel showed the same degree of inflammation as that of the negative control at 1 week, and then, showed a gradually absorbable property at 4 and 6 weeks. This gel has a potential to be applied as an absorbable implant. The PAMPS/polyacrylamide and Cellulose/PDMAAm gels induced a significant inflammation at each week. These DN gels are difficult to be applied as clinical implants in the current situation.