Neuroprotective effects of P7C3 against spinal cord injury in rats
Neuroprotective effects of P7C3 against spinal cord injury in rats
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P7C3对大鼠脊髓损伤的神经保护作用
DOI：
10.1177/1535370219888620
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发表时间：
2019-11-13
影响因子：
3.2
通讯作者：
Hu, Jian-Guo
中科院分区：
文献类型：
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作者：
Duan, Fei-Xiang;Shi, Yu-Jiao;Hu, Jian-Guo
脊髓损伤（SCI）是一种严重的神经系统疾病，治疗干预很少。P7C3是一种小分子，已被证实在某些神经系统疾病中发挥神经保护作用。但P7C3在急性脊髓损伤中的作用尚未见报道。在此，我们观察了P7C3在大鼠模型中通过在SCI后直接皮下注射每天一次持续7或14天来减轻神经损伤的治疗效果。观察大鼠运动功能和组织病理学变化。我们的研究结果表明，P7C3治疗有助于SCI后的功能恢复和组织修复。P7C3治疗改善运动功能与神经元和少突胶质细胞（OLs）的存活增加以及OLs及其祖细胞的增殖相关，这导致了受损SC中的组织修复和髓鞘形成。P7C3治疗还恢复了SC中的烟酰胺腺嘌呤二核苷酸水平，该水平被SCI降低。这些结果表明，P7C3在改善SCI后的神经功能方面发挥作用。脊髓损伤（SCI）是一种严重的神经系统疾病，治疗干预很少。这项研究首次证实了P7C3有助于SCI后的功能恢复和组织修复。P7C3治疗可以拯救受损脊髓的烟酰胺腺嘌呤二核苷酸水平，这导致神经元和少突胶质细胞（OL）的更多存活以及OL及其祖细胞的增殖，从而增加髓鞘形成和组织修复。这一结果表明，P7C3在改善SCI后的神经功能方面发挥作用。
Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. A small molecule, P7C3, has been confirmed to play a role in neuroprotection of some neurological diseases. But the effect of P7C3 on acute SCI has not been investigated. Here, we observed the therapeutic effect of P7C3 for alleviating the neurological damage by direct subcutaneous injection after SCI once daily for 7 or 14 days in a rat model. The locomotion and histopathological changes were evaluated. Our results demonstrated that P7C3 treatment contributed to functional recovery and tissue repair following SCI. Improved locomotor function with P7C3 treatment was correlated with increased survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, which resulted in tissue repair and myelination in the injured SC. P7C3 treatment also restored the nicotinamide adenine dinucleotide level in the SC, which was reduced by SCI. These results suggest that P7C3 plays a role in improving neurological outcome following SCI. Impact statement Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. This study confirms for the first time that P7C3 is conducive to functional recovery and tissue repair after SCI. P7C3 treatment can rescue the nicotinamide adenine dinucleotide level of the injured spinal cord, which results in more survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, and thus increase myelination and tissue repair. This result indicates that P7C3 plays a role in improving neurological outcome following SCI.