Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
复制标题
人球孢子菌病中外周血单核细胞产生细胞因子。
DOI：
10.1093/infdis/174.2.440
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Galgiani,JN
中科院分区：
文献类型：
--
作者：
Corry,DB;Ampel,NM;Christian,L;Locksley,RM;Galgiani,JN
The production and mRNA expression of the cytokines interferon-γ (IFN-γ) and interleukin (IL)-4, -10, and -12 by peripheral blood mononuclear cells (PBMC) after incubation with the coccidioidal antigen toluene spherule lysate (TSL) from various subjects were measured. The IFN-y concentration in PBMC supernatants incubated for 72 h from 8 subjects with disseminated coccidioidomycosis was significantly less than that from 7 healthy, coccidioidal-immune subjects (P= .015). No differences were seen among the subject groups in the concentrations of IL-4, -10, or -12. By use of competitive polymerase chain reaction, PBMC from subjects with disseminated coccidioidomycosis also expressed less mRNA for IFN-γ and IL-12 than did cells from healthy, immune subjects. These data suggest that patients with disseminated coccidioidomycosis have a diminished T helper lymphocyte type 1 response.
