ENAMEL FLUOROSIS RELATED TO PLASMA-F LEVELS IN THE RAT
ENAMEL FLUOROSIS RELATED TO PLASMA-F LEVELS IN THE RAT
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DOI：
10.1159/000260743
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发表时间：
1984-01-01
期刊：
影响因子：
4.2
通讯作者：
WHITFORD, GM
中科院分区：
文献类型：
--
作者：
ANGMARMANSSON, B;WHITFORD, GM
研究了与低但相对恒定的血浆氟[F-]水平相关的牙釉质矿化障碍，这些血浆氟[F-]水平由恒定输注产生，或与饮用氟化水引起的血浆F-水平波动相关。断奶大鼠饲养8周，低F-食物和水含有0，10，25或60 ppm的F-。另外两组从s.c.植入微型泵。后两组的每日氟暴露量分别为0.14和0.32 mg/天，而10 ppm水组的平均氟暴露量为0.41 mg/天。10 ppm水组的终末血浆F-水平为3.0 μ M，2个微泵组分别为1.5和3.1 μ M。各组中的下颌切牙釉质显示出氟中毒变化的显微放射照相证据，这在微型泵组中最严重，平均血浆F-浓度为3.1 μ M。釉质矿化的干扰在25和60 ppm水组中最明显。各组间血浆Ca浓度无差异。氟牙釉质症除了有浓度或摄入成分外，还有时间成分。大鼠切牙是一个更好的模型，人类釉质氟中毒比以前认为。氟牙釉质症不一定与钙稳态失调有关。
Disturbances in enamel mineralization associated with low, but relatively constant, plasma fluoride [F-] levels produced by constant infusion or with fluctuating plasma F- levels caused by drinking fluoridated water were studied. Weanling rats were raised for 8 wk on low-F- food and water containing 0, 10, 25 or 60 ppm F-. Two other groups received their F- from s.c. implanted minipumps. The daily F- exposure of the 2 latter groups was 0.14 and 0.32 mg/day, while that of the 10 ppm water group averaged 0.41 mg/day. The terminal plasma F- level of the 10 ppm water group was 3.0 .mu.M, and of the 2 minipump groups were 1.5 and 3.1 .mu.M, respectively. The mandibular incisor enamel in each group showed microradiographic evidence of fluorotic changes which was most severe in the minipump group with an average plasma F- concentration of 3.1 .mu.M. The disturbances in enamel mineralization were most apparent in the 25 and 60 ppm water groups. There were no differences among the groups for plasma Ca concentrations. Enamel fluorosis had a time component in addition to a concentration or intake component. The rat incisor was a better model for human enamel fluorosis than previously believed. Disorders in Ca homeostasis were not necessarily involved in enamel fluorosis.