From cells to tissue: A continuum model of epithelial mechanics
From cells to tissue: A continuum model of epithelial mechanics
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DOI：
10.1103/physreve.96.022418
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发表时间：
2017-08-31
影响因子：
2.4
通讯作者：
Sugimura, Kaoru
中科院分区：
文献类型：
--
作者：
Ishihara, Shuji;Marcq, Philippe;Sugimura, Kaoru
一个二维连续模型的上皮组织力学制定使用细胞水平的机械成分和细胞形态发生过程，包括细胞形状的变化和细胞重排。该模型包括应力和变形张量，可以与实验数据进行比较。聚焦于细胞形状变化和细胞重排之间的相互作用，我们阐明了被动松弛、主动收缩-伸长和组织剪切流的动力学行为，包括收缩-伸长机制，即组织垂直于细胞伸长轴流动。这项研究提供了一个完整的方案，为理解在个别细胞的形态发生过程的编排，以实现上皮组织形态发生。
A two-dimensional continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model incorporates stress and deformation tensors, which can be compared with experimental data. Focusing on the interplay between cell shape changes and cell rearrangements, we elucidated dynamical behavior underlying passive relaxation, active contraction-elongation, and tissue shear flow, including a mechanism for contraction-elongation, whereby tissue flows perpendicularly to the axis of cell elongation. This study provides an integrated scheme for the understanding of the orchestration of morphogenetic processes in individual cells to achieve epithelial tissue morphogenesis.