F1-ATPase: a highly efficient rotary ATP machine.

F1-ATPase: a highly efficient rotary ATP machine.
复制标题

F1-ATPase:高效旋转 ATP 机器。

DOI:
10.1042/bse0350003
复制
发表时间:
2000
影响因子:
6.4
通讯作者:
Hiroyuki Noji
Hiroyuki Noji
中科院分区:
生物学2区
文献类型:
--
作者:
K. Kinosita;K. Kinosita;R. Yasuda;Hiroyuki Noji

文献摘要

参考文献

被引文献

相似文献

f1 - atp酶的单个分子本身就是一个旋转马达,其中一个中心亚基,绕着周围由- 3 - 3六聚体组成的定子圆柱旋转。由三个β亚基依次水解ATP驱动,马达在低ATP浓度下以离散的120度步进运行。在很宽的负载和速度范围内,电机产生恒定的扭矩为40 pN.nm。电机在120度步进中所做的机械功,或每个ATP水解的功,也是恒定的,达到80- 90pn。nm,接近ATP水解的自由能。因此,这个电机可以在接近100%的效率工作。
A single molecule of F1-ATPase is by itself a rotary motor in which a central subunit, gamma, rotates against a surrounding stator cylinder made of alpha 3 beta 3 hexamer. Driven by the three beta subunits that hydrolyse ATP sequentially, the motor runs with discrete 120 degrees steps at low ATP concentrations. Over broad ranges of load and speed, the motor produces a constant torque of 40 pN.nm. The mechanical work the motor does in the 120 degrees step, or the work per ATP hydrolysed, is also constant and amounts to 80-90 pN.nm, which is close to the free energy of ATP hydrolysis. Thus this motor can work at near 100% efficiency.
DOI: 10.1016/s0006-3495(94)80537-5
发表时间: 1994-08-01
影响因子: 3.4
作者:
HUNT, AJ;GITTES, F;HOWARD, J
通讯作者: HOWARD, J
DOI: 10.1073/pnas.92.24.10964
发表时间: 1995-11-21
影响因子: 11.1
作者:
DUNCAN, TM;BULYGIN, VV;CROSS, RL
通讯作者: CROSS, RL