Inner Secrets of the Respirasome.
Inner Secrets of the Respirasome.
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DOI：
10.1016/j.cell.2016.11.025
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发表时间：
2016-12-01
期刊：
影响因子：
64.5
通讯作者：
Winge DR
中科院分区：
文献类型：
--
作者：
Melber A;Winge DR
冷冻电子显微镜的结构测定已接近原子分辨率，并有助于解析那些难以用晶体学方法解析的大型膜蛋白复合物的结构。本期《细胞》杂志报道了位于线粒体内膜的最复杂的酶系统之一——呼吸体的4.0 Å冷冻电镜结构。
Structure determination by cryo-electron microscopy has approached atomic resolution and helped solve structures of large membrane-protein complexes that resisted crystallography. The 4.0 Å cryo-EM structure of one of the most intricate enzyme systems, the respirasome, in the mitochondrial inner membrane is reported in this issue of Cell.