Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with men
Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with men
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DOI：
10.7196/samj.7002
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
McIntyre, J A
中科院分区：
文献类型：
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作者：
Rebe, K B;de Swardt, G;McIntyre, J A
背景。男男性行为者（MSM）感染和传播艾滋病毒的风险很高。无保护肛交（UAI）有很高的艾滋病毒传播潜力，这需要性润滑来进行舒适、非创伤性的肛交。在许多发展中国家，润滑剂的分布仍然很差，众所周知，男男性行为者会用一些常见的家用或食品产品来替代，以确保舒适的肛交。肛交中使用的润滑剂的潜在毒性引起了人们的关注。上皮损伤与润滑油产品的渗透压有关。分析市售的水性性润滑剂产品，以确定其渗透压和潜在的直肠上皮损伤。测定了8种最常购买的水性性润滑剂和一些常用的家用/食品产品的渗透压和甘油浓度。渗透压范围为270 - 9440 mosmol/l（分别含有植物角鲨烷的Lubrimaxxx Premium和JO H2O水基润滑剂）。7种（88%）商品润滑油存在高渗透压，其中2种产品渗透压接近1万mosmol/l，远远超过渗透压接近280 mosmol/l的血清。这项研究的结果表明，在美国，许多最畅销的水性性润滑剂品牌都是高渗透压的。鉴于高渗透性产品在体外和体内均可引起上皮损伤，如果在UAI期间使用，它们可能会增加HIV的获取和传播。需要提高人们对设计用于肛交的润滑剂的粘膜安全性的认识。
Background. Men who have sex with men (MSM) are at high risk for HIV acquisition and transmission. There is a high HIV-transmission potential associated with unprotected anal intercourse (UAI), which requires sexual lubrication for comfortable, non-traumatic anal sex. Lubritant distribution remains poor in many developing nations and MSM have been known to substitute a number of common household or food products to ensure comfortable anal sex. Concern has been raised about the potential toxicity of lubricants used during anal sex. Epithelial injury is related to-the osmolality of the lubricant product.Objective. To analyse commercially available water-based sexual lubricant products to ascertain their osmolality and potential to cause rectal epithelial damage.Methods. The osmolality and glycerol concentration was determined for eight of the most frequently purchased water-based sexual lubricants and some commonly used household/food products.Results. Osmolality ranged from 270 - 9 440 mosmol/l (Lubrimaxxx Premium, containing phytosqualane, and JO H2O Water Based Lubricant, respectively). Seven (88%) of the commercial lubricants had high osmolalities, with two products approaching 10 000 mosmol/l, far in excess of serum which has an osmolality of similar to 280 mosmol/l.Conclusion. The results of this study show that many of the top-selling brands of water-based sexual lubricants available in SA are hyperosmolar. Given that hyperosmolar products have been shown in vitro and in vivo to cause epithelial injury, they may have the potential to increase HIV acquisition and transmission, if they are used during UAI. Awareness needs to be raised about the mucosal safety of lubricants designed for use during anal sex.