Lack of long-term effect of vitamin C supplementation on blood pressure
Lack of long-term effect of vitamin C supplementation on blood pressure
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DOI：
10.1161/01.hyp.0000038339.67450.60
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发表时间：
2002-12-01
期刊：
影响因子：
8.3
通讯作者：
Tsugane, S
中科院分区：
文献类型：
--
作者：
Kim, MK;Sasaki, S;Tsugane, S
在一项双盲随机对照试验中，我们研究了维生素C补充剂对血压的长期影响。共有439名患有萎缩性胃炎的日本受试者最初参加了使用维生素C和β-胡萝卜素预防胃癌的试验。在β-胡萝卜素补充剂提前终止之前和终止时，134名受试者退出了这项试验，而120名和124名受试者分别每天服用50 mg或500 mg维生素C补充剂，持续5年。补充维生素C前，收缩压和舒张压与血清维生素C浓度均无显著相关。在调整年龄、体重指数和酒精摄入量或按性别分层后，这种关系没有变化。5年后，与基线相比，无论维生素C剂量如何，各组的收缩压均显著升高。高剂量组（每日500 mg）的收缩压从125.4 mmHg升高至131.7 mmHg（升高5.88 mmHg; 95%置信区间[CI]，3.11至8.65）。该值与低剂量组（升高5.73 mmHg; 95% CI，2.62 - 8.83）和脱落组（升高4.52 mmHg; 95% CI，1.26 - 7.77）相似。3组间舒张压变化无差异。总之，我们在胃癌和中风高危人群中观察到长期中等剂量（500 mg/天）维生素C补充剂没有降低血压。
In a double-blinded randomized controlled trial, we investigated the long-term effect of vitamin C supplementation on blood pressure. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and beta-carotene to prevent gastric cancer. Before and on early termination of beta-carotene supplementation, 134 subjects dropped out of this trial, whereas 120 and 124 subjects took the vitamin C supplement daily at either 50 mg or 500 mg, respectively, for 5 years. Before supplementation, neither systolic nor diastolic blood pressure was significantly related with the serum vitamin C concentration. This relationship was unchanged after adjustment for age, body mass index, and alcohol intake or after stratification by gender. After 5 years, systolic blood pressure significantly increased in groups, regardless of vitamin C dose, compared with baseline. Systolic blood pressure in the high-dose group (500 mg daily) increased from 125.4 to 131.7 mm Hg (5.88 mm Hg increase; 95% confidence interval [CI], 3.11 to 8.65). This value was similar with that of the low-dose group (5.73 mm Hg increase; 95% CI, 2.62 to 8.83) and of the dropout group (4.52 mm Hg increase; 95% CI, 1.26 to 7.77). There was no difference in change of diastolic blood pressure among the 3 groups. In conclusion, we observed no reduction in blood pressure with long-term moderate doses (500 mg/day) of vitamin C supplementation in a high-risk population for stomach cancer and stroke.