Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity.
Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity.
复制标题
茉莉酸葡萄糖苷的糖部分对于生物活性和靶标亲和力的功能重要性。
DOI：
10.1039/c4ob02106a
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Ueda;M.; Yang;G.; Nukadzuka;Y.; Ishimaru;Y.; Tamura;S.; Manabe;Y.
12-O-β-D-Glucopyranosyljasmonic acid （JAG, 1）诱导沙曼草（Samanea saman）叶片动态折叠。对1的SAR研究揭示了其糖元部分的独特作用。1的生物活性和靶标亲和力受到糖元部分立体化学性质的影响。JAG是一类独特的配体，其糖元部分的结构参与了靶蛋白的分子识别。
12-O-β-D-Glucopyranosyljasmonic acid (JAG, 1) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of 1 revealed the unique role of its glycone moiety. Biological activity and the target affinity of 1 were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure of the glycone moiety is involved in the molecular recognition by the target protein.