The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. The role of transmitters
The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. The role of transmitters
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DOI：
10.1016/s0006-8993(00)02579-8
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发表时间：
2000-08
期刊：
影响因子：
2.9
通讯作者：
G. Telegdy;K. Kokavszky
中科院分区：
文献类型：
--
作者：
G. Telegdy;K. Kokavszky
在本研究中，PACAP 38单向被动回避学习的行动进行了调查。将PACAP-38注入侧脑室，24 h后测量被动回避反应的潜伏期。为了研究各种神经递质在介导PACAP巩固被动回避学习的作用中的可能作用，动物用受体阻断剂预先处理，其剂量本身被证明是无效的。PACAP促进被动回避反应的学习、巩固和提取。以下受体阻滞剂减弱PACAP对这种巩固的作用：氟哌啶醇，酚苄明，普萘洛尔和麦角新碱。PACAP 38的拮抗剂PACAP 6-38以及硝基-L-精氨酸（后者阻断一氧化氮合酶），从而抑制从L-精氨酸形成NO，完全阻断了PACAP 38对巩固的作用。以下受体阻滞剂无效：纳洛酮、荷包牡丹碱和阿托品。所呈现的数据表明，PACAP 38能够改善被动回避范例中的学习和记忆过程。在这一作用中，PACAP 38受体和NO是重要的介质。多巴胺能、α-和β-肾上腺素能介导和5-羟色胺受体改变了PACAP 38的作用，但它们可能并不重要。
In the present study, the action of PACAP 38 on one-way passive avoidance learning was investigated. PACAP-38 was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. In order to study the possible roles of various neurotransmitters in mediating the action of PACAP on the consolidation of passive avoidance learning, the animals were pre-treated with receptor blockers in doses that per se proved to be ineffective. PACAP facilitated the learning, the consolidation of learning and the retrieval of the passive avoidance response. The following receptor blockers attenuated the action of PACAP on this consolidation: haloperidol, phenoxybenzamine, propranolol and methysergide. An antagonist of PACAP 38, PACAP 6-38, and also nitro-l-arginine (the latter blocks the enzyme nitric oxide synthase) thereby inhibiting the formation of NO from l-arginine, completely blocked the action of PACAP 38 on consolidation. The following receptor blockers were ineffective: naloxone, bicuculline and atropine. The presented data suggest that PACAP 38 is able to improve the learning and memory processes in a passive avoidance paradigm. In this action, the PACAP 38 receptor and NO are important mediators. Dopaminergic, alpha- and beta-adrenergic mediation and serotonin receptors modified the action of PACAP 38, but they are probably not of great importance.