ORAL CONDITION OF PATIENTS WITH LEUKEMIA AND SEVERE APLASTIC-ANEMIA - FOLLOW-UP 1 YEAR AFTER BONE-MARROW TRANSPLANTATION
ORAL CONDITION OF PATIENTS WITH LEUKEMIA AND SEVERE APLASTIC-ANEMIA - FOLLOW-UP 1 YEAR AFTER BONE-MARROW TRANSPLANTATION
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DOI：
10.1016/0030-4220(85)90238-5
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
RINGDEN, O
中科院分区：
文献类型：
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作者：
HEIMDAHL, A;JOHNSON, G;RINGDEN, O
对20例白血病患者和7例重型再生障碍性贫血患者进行了骨髓移植治疗，并在移植后1年对他们的口腔状况进行了评估。10例患者有轻度临床慢性移植物抗宿主病（GVHD），3例患者有中度或重度GVHD。在19例患者中观察到口腔粘膜或小唾液腺的组织学变化。在这些患者中的16例中观察到口腔粘膜的临床变化。白色念珠菌定植在口腔粘膜组织病理学改变较严重的患者中更为常见。变形链球菌和乳酸杆菌的数量及全唾液流率与龋病发生率的高低无关。全唾液流率与GVHD无关，但与全身照射预处理相关（p < 0.05）。
Twenty patients with leukemia and seven patients with severe aplastic anemia who had been treated with bone marrow transplantation were investigated 1 year after transplantation to assess their oral condition. Ten patients had mild clinical chronic graft-vs-host disease (GVHD), and three patients had moderate or severe GVHD. Histopathologic changes in the oral mucosa or the minor salivary glands were observed in nineteen patients. Clinical changes in the oral mucosa were observed in sixteen of those patients. Colonization with Candida albicans was more frequent in patients with advanced histopathologic changes in oral muscosa. The numbers of Streptococcus mutans and lactobacilli and the whole salivary flow rate were not correlated to high or low caries incidence. Whole salivary flow rate were not correlated to GVHD but rather, to conditioning with total body irradiation (p < 0.05).