BACTERICIDAL EFFECT FOR HUMAN LACTOFERRIN
BACTERICIDAL EFFECT FOR HUMAN LACTOFERRIN
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DOI：
10.1126/science.327545
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
MCGHEE, JR
中科院分区：
文献类型：
--
作者：
ARNOLD, RR;COLE, MF;MCGHEE, JR
变形链球菌和霍乱弧菌，但不是大肠杆菌，通过与纯化的人脱铁乳铁蛋白孵育被杀死。乳铁蛋白的浓度低于总抑制所需的浓度导致活菌落形成单位的显著减少。这种杀菌作用取决于乳铁蛋白分子的金属螯合特性。
Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.