The evolution of bacterial LuxI and LuxR quorum sensing regulators
The evolution of bacterial LuxI and LuxR quorum sensing regulators
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DOI：
10.1099/00221287-147-8-2379
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发表时间：
2001-08-01
期刊：
影响因子：
2.8
通讯作者：
Garey, JR
中科院分区：
文献类型：
--
作者：
Gray, KM;Garey, JR
群体感应是细菌通讯的一种普遍形式，其中单个细胞产生并响应特定的N-酰基高丝氨酸内酯信号代谢物。产生这些信号的不同的自诱导物激酶和介导细胞对它们的应答的受体/激活蛋白构成分别被称为LuxI和LuxR家族的调节蛋白的进化上保守的家族。我们已经进行了76个单独的LuxI和LuxR同系物存在于革兰氏阴性变形菌的不同成员的系统发育分析。这些监管机构的变形菌进化过程中的早期起源的结果是一致的，luxI和luxR基因的功能对可能共同进化的监管盒。在许多情况下，特定的LuxI和LuxR家族成员似乎是水平遗传的。特别是，那些含有多个LuxI和/或LuxR同源物的物种通常似乎已经从一个独立的来源获得了每个单独的同源物或功能对的同源物。由于多个同源物相互作用，形成监管级联，这一发现表明，分层信号通路可能会演变的顺序整合预先存在的监管电路从不同的来源。
Quorum sensing is a widespread form of bacterial communication in which individual cells produce and respond to specific N-acyl homoserine lactone signal metabolites. The different autoinducer synthases that generate these signals and the receptor/activator proteins that mediate the cell's response to them constitute evolutionarily conserved families of regulatory proteins known as the LuxI and LuxR families, respectively. We have performed a phylogenetic analysis of 76 individual LuxI and LuxR homologues present in diverse members of the Gram-negative Proteobacteria. The results were consistent with an early origin for these regulators during the evolution of the Proteobacteria, with functional pairs of luxI and luxR genes possibly coevolving as regulatory cassettes. In many cases, specific LuxI and LuxR family members appeared to have been inherited horizontally. In particular, those species containing multiple LuxI and/or LuxR homologues usually appeared to have obtained each individual homologue or functional pair of homologues from an independent source. Because multiple homologues interact to form regulatory cascades, this finding suggests that hierarchical signalling pathways can potentially evolve by the sequential integration of pre-existing regulatory circuits acquired from diverse sources.