Acute diffusion abnormalities in the hippocampus of children with new-onset seizures: the development of mesial temporal sclerosis
Acute diffusion abnormalities in the hippocampus of children with new-onset seizures: the development of mesial temporal sclerosis
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DOI：
10.1007/s00234-003-1122-x
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发表时间：
2004-04-01
期刊：
影响因子：
2.8
通讯作者：
Bilaniuk, LT
中科院分区：
文献类型：
--
作者：
Farina, L;Bergqvist, C;Bilaniuk, LT
我们研究了早期弥散加权成像DWI在调查儿童新发长期癫痫发作，最终导致单侧海马硬化（HS）的作用。我们对5名17个月至7岁的儿童进行了MRI，包括常规序列和扩散加权序列。我们计算了受影响和正常对侧海马的表观扩散系数（ADC）。4例进行DWI和ADC测量。我们研究了4名儿童在3天内发作的长期精神性癫痫发作，并显示增加的信号T2加权图像，DWI，表明限制扩散，整个受影响的海马。海马头部ADC值平均降低14.4%，海马体部ADC值平均降低15%。1例患儿发作后15天检查，双侧ADC值相同。5例患者随访2-18个月均出现海马萎缩。在随访时获得ADC的4例患者中，头部ADC增加了19%，身体增加了17%。DWI可能是常规MRI的一个有用的辅助手段，用于识别导致硬化的海马急性损伤。
We studied the role of early diffusion-weighted imaging DWI in the investigation of children with new-onset prolonged seizures which eventually result in unilateral hippocampal sclerosis (HS). We carried out MRI on five children aged 17 months to 7 years including conventional and diffusion-weighted sequences. We calculated apparent diffusion coefficients (ADC) for the affected and the normal opposite hippocampus. Follow-up examinations were performed, including DWI and ADC measurements in four. We studied four children within 3 days of the onset of prolonged psychomotor seizures and showed increased signal on T2-weighted images, and DWI, indicating restricted diffusion, throughout the affected hippocampus. The ADC were reduced by a mean of 14.4% in the head and by 15% in the body of the hippocampus. In one child examined 15 days after the onset of seizures, the ADC were the same on both sides. All five patients showed hippocampal atrophy on follow-up 2-18 months later. In the four patients in whom ADC were obtained on follow-up, they were increased by 19% in the head and 17% in the body. DWI may represent a useful adjunct to conventional MRI for identifying acute injury to the hippocampus which results in sclerosis.