Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant
Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant
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DOI：
10.1016/j.actbio.2012.08.028
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发表时间：
2013-11-01
影响因子：
9.7
通讯作者：
Reifenrath, Janin
中科院分区：
文献类型：
--
作者：
Dziuba, Dina;Meyer-Lindenberg, Andrea;Reifenrath, Janin
镁合金是骨接合术中可吸收材料的研究重点，因为它们提供了足够的稳定性，并且不需要手术取出植入物。为了提高镁合金的稳定性和耐腐蚀性，通过添加锌、稀土和锆，研制了一种新型可降解镁合金ZEK100。由于在先前的体内研究中植入6个月后植入物仅降解至有限程度，因此进行本研究以评价相同动物模型中9个月和12个月的长期降解行为和生物相容性。在9个月和12个月期间，对5只植入胫骨髓内植入物的家兔进行了检查。留下三条没有植入物的腿作为阴性对照。在随访（临床检查、血清分析、放射学和体内显微CT研究）和死亡后（离体显微CT、组织学和植入物分析）进行了大量检查，以评估体内降解和生物相容性。可以证明，有利的体内降解行为不一定与良好的生物相容性相关。尽管ZEK100提供了非常高的初始稳定性和积极的生物降解性，但必须将其从进一步的生物医学测试中排除，因为它在完全降解后对宿主组织显示出病理学效应。(C)2012 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Magnesium alloys are the focus of research as resorbable materials for osteosynthesis, as they provide sufficient stability and would make surgery to remove implants unnecessary. The new degradable magnesium alloy ZEK100 was developed to improve the stability and corrosion resistance by alloying with zinc, rare earth metals and zirconium. As the implants were degraded to only a limited extent after 6 months implantation in a previous in vivo study the present study was conducted to evaluate the long-term degradation behaviour and biocompatibility in the same animal model over 9 and 12 months. Five rabbits each with intramedullary tibia implants were examined over 9 and 12 months. Three legs were left without an implant to serve as negative controls. Numerous examinations were performed in the follow-up (clinical examinations, serum analysis, and radiographic and in vivo micro-CT investigations) and after death (ex vivo micro-CT, histology, and implant analysis) to assess the in vivo degradation and biocompatibility. It could be shown that favourable in vivo degradation behaviour is not necessarily associated with good biocompatibility. Although ZEK100 provided a very high initial stability and positive biodegradation, it must be excluded from further biomedical testing as it showed pathological effects on the host tissue following complete degradation. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.