Hematopoietic and immune recovery after transplantation of cord blood progenitor cells in children.
Hematopoietic and immune recovery after transplantation of cord blood progenitor cells in children.
复制标题
儿童脐带血祖细胞移植后造血和免疫恢复。
DOI：
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发表时间：
1996
影响因子：
4.8
通讯作者：
F. Severi
中科院分区：
文献类型：
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作者：
F. Locatelli;R. Maccario;P. Comoli;F. Bertolini;G. Giorgiani;D. Montagna;F. Bonetti;P. Stefano;G. Rondini;G. Sirchia;F. Severi
亲属配对脐血移植（CBT）已成功地用于挽救接受清髓治疗的患者。然而，很少有数据可用于CBT收件人的血液学和免疫重建的动力学。我们研究了3例急性淋巴细胞白血病患者的血液学植入和相关CBT后的免疫恢复，这些患者年龄分别为10岁、9岁和7岁，体重分别为31、40和25 kg。所有植入的患者均未发生急性或慢性移植物抗宿主病。粒细胞恢复所需时间分别为13、26和29天，血小板恢复分别为28、49和51天。所有患者的HbF均显著增加，观察到的值远大于接受骨髓移植的患者的记录值，并且与第一年年龄的正常儿童中观察到的值相当。T细胞免疫的恢复以及自然杀伤细胞亚群的恢复与BMT接受者中描述的相似，即CD 8 + T细胞的更快恢复决定了CD 4/CD 8比率的特征性倒置。B淋巴细胞的百分比和绝对数量显著增加，显然与病毒感染无关，在所有3例病例中均得到证实。这些数据表明，与接受BMT的患者相比，接受CBT的患者在血液学恢复方面可能会出现轻微延迟。红细胞生成的重建似乎重现了BMT后观察到的个体发育模式和免疫系统恢复的动力学，具有外周血中B细胞扩增的特点。
Matched related cord blood transplantation (CBT) has been successfully used to rescue patients undergoing myeloablative therapy. However, few data are available on the kinetics of hematological and immunological reconstitution of CBT recipients. We have investigated the hematological engraftment and immune recovery following related CBT in three patients, with acute lymphoblastic leukemia, aged 10, 9 and 7 years and with a body weight of 31, 40 and 25 kg, respectively. All patients engrafted and none experienced acute or chronic graft-versus-host disease. The time needed to achieve granulocyte recovery was 13, 26 and 29 days, respectively and platelet recovery occurred in 28, 49 and 51 days. All patients presented a marked increase of HbF, the values observed being much greater than those documented in patients given marrow transplantation and comparable with those observed in normal children in the first year of age. The recovery of T cell immunity, as well as that of natural killer subpopulations, mimicked that described in BMT recipients, a quicker return of CD8+ T cells determining the characteristic inversion of CD4/CD8 ratio. An impressive increase in the percentage and absolute number of B lymphocytes, apparently not related to viral infections, was demonstrable in all three cases. These data suggest that CBT recipients can experience a slight delay in hematological recovery when compared with patients given BMT. The reconstitution of erythropoiesis seems to recapitulate the ontogenetic pattern and the kinetics of recovery of the immune system reproduce that observed after BMT with the peculiarity of B cell expansion in peripheral blood.