THE INTERFERONS - A BIOLOGICAL SYSTEM WITH THERAPEUTIC POTENTIAL IN VIRAL-INFECTIONS
THE INTERFERONS - A BIOLOGICAL SYSTEM WITH THERAPEUTIC POTENTIAL IN VIRAL-INFECTIONS
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DOI：
10.1016/0166-3542(94)90058-2
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发表时间：
1994-07-01
影响因子：
7.6
通讯作者：
DIANZANI, F
中科院分区：
文献类型：
--
作者：
BARON, S;DIANZANI, F
干扰素治疗慢性病毒感染的成功医学应用越来越依赖于对干扰素系统的生物学和分子机制的理解。干扰素（IFN）是人体的天然防御之一。IFN的产生是对微生物、肿瘤和抗原的外来成分的防御反应。这种IFN应答开始于IFN蛋白（α、β和γ）的产生，然后诱导抗病毒、抗微生物、抗肿瘤和免疫调节作用。因此，IFN的初始产生或施用并不直接保护，而是与细胞表面上的特异性受体反应以激活细胞质转导信号，然后细胞质转导信号进入细胞核以刺激编码导致防御作用的许多效应蛋白的细胞基因。已知的分子，体液和细胞机制，这些效应蛋白发挥其抗病毒活性。此外，慢性感染的发病机制概述的背景下，干扰素的防御。
Successful medical use of interferon for chronic viral infections is increasingly dependent on understanding the biologic and molecular mechanisms of the interferon system. Interferon (IFN) is one of the body's natural defenses. Production of IFN is a defensive response to foreign components of microbes, tumors and antigens. This IFN response begins with the production of the IFN proteins (alpha, beta and gamma) which then induce antiviral, antimicrobial, antitumor, and immunomodulatory actions. Thus, the initial production or administration of IFN(s) does not protect directly but instead reacts with specific receptors on cell surfaces to activate cytoplasmic transduction signals that then enter the nucleus to stimulate cellular genes encoding a number of effector proteins which lead to the defensive actions. The known molecular, humoral and cellular mechanisms by which these effector proteins exert their antiviral activities are presented. In addition, the pathogenesis of chronic infections is overviewed in the context of the interferon defenses.