Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
复制标题
DOI：
10.1039/b501932j
复制
发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Sun, HD
中科院分区：
文献类型：
--
作者：
Li, RT;Han, QB;Sun, HD
从五味子中分离得到两个新的高氧去甲内酯B和C(1-2)，它们具有独特的正环阿糖烷骨架，对HIV-1复制的EC50值为7.71微克/毫升(SI>；25.94)，细胞毒性最小，2具有强大的抗HIV-1活性和独特的结构特征，有望成为新一代抗HIV药物治疗开发的先导化合物。
Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C ( 2) exhibited an EC50 value of 7.71 mu g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.