Frontal brain asymmetry in adult attention-deficit/hyperactivity disorder (ADHD): Extending the motivational dysfunction hypothesis
Frontal brain asymmetry in adult attention-deficit/hyperactivity disorder (ADHD): Extending the motivational dysfunction hypothesis
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DOI：
10.1016/j.clinph.2014.07.008
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发表时间：
2015-04-01
影响因子：
4.7
通讯作者：
Schoenenberg, Michael
中科院分区：
文献类型：
--
作者：
Keune, Philipp M.;Wiedemann, Eva;Schoenenberg, Michael
目的：注意缺陷/多动障碍（ADHD）涉及动机功能障碍，以过度行为倾向为特征。静息状态脑电图（EEG）中α带（8-13 Hz）的额叶脑不对称代表了整体动机倾向的神经关联，在儿童和成人患者中观察到异常不对称，表明接近动机升高。迄今为止，ADHD症状、抑郁和α不对称之间的关系、其时间度量特性和假定的性别特异性仍有待探索。方法：成人ADHD患者52例，每隔2周进行2次静息状态EEG记录。不对称测量在记录中汇总，以增加性状特异性。对不对称、ADHD症状和抑郁之间假定的区域特异性关联、其性别特异性和重测信度进行了检验。结果：ADHD症状与入路相关的不对称性相关（较强的相对右额叶α功率）。与接近相关的不对称在女性中很明显，也与抑郁有关。后一种关联是由ADHD症状介导的。重测信度足够。结论：可可靠评估的α不对称与ADHD症状之间的关联支持动机功能障碍假说。ADHD症状介导不对称和抑郁之间的非典型关联可能归因于继发于ADHD的抑郁。针对性别的调查结果需要复制。意义：额叶α不对称可能是ADHD症状的一个新的可靠标志。(C) 2014年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Attention-deficit/hyperactivity disorder (ADHD) involves motivational dysfunction, characterized by excessive behavioral approach tendencies. Frontal brain asymmetry in the alpha band (8-13 Hz) in resting-state electroencephalogram (EEG) represents a neural correlate of global motivational tendencies, and abnormal asymmetry, indicating elevated approach motivation, was observed in pediatric and adult patients. To date, the relation between ADHD symptoms, depression and alpha asymmetry, its temporal metric properties and putative gender-specificity remain to be explored.Methods: Adult ADHD patients (n = 52) participated in two resting-state EEG recordings, two weeks apart. Asymmetry measures were aggregated across recordings to increase trait specificity. Putative region-specific associations between asymmetry, ADHD symptoms and depression, its gender-specificity and test-retest reliability were examined.Results: ADHD symptoms were associated with approach-related asymmetry (stronger relative right-frontal alpha power). Approach-related asymmetry was pronounced in females, and also associated with depression. The latter association was mediated by ADHD symptoms. Test-retest reliability was sufficient.Conclusions: The association between reliably assessable alpha asymmetry and ADHD symptoms supports the motivational dysfunction hypothesis. ADHD symptoms mediating an atypical association between asymmetry and depression may be attributed to depression arising secondary to ADHD. Gender-specific findings require replication.Significance: Frontal alpha asymmetry may represent a new reliable marker of ADHD symptoms. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.