Inositol 1,3,4,5-tetrakisphosphate-gated channels interact with inositol 1,4,5-trisphosphate-gated channels in olfactory receptor neurons.
Inositol 1,3,4,5-tetrakisphosphate-gated channels interact with inositol 1,4,5-trisphosphate-gated channels in olfactory receptor neurons.
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肌醇 1,3,4,5-四磷酸门控通道与嗅觉受体神经元中的肌醇 1,4,5-三磷酸门控通道相互作用。
DOI：
10.1073/pnas.91.20.9471
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发表时间：
1994
影响因子：
11.1
通讯作者：
Ache,BW
中科院分区：
文献类型：
--
作者：
Fadool,DA;Ache,BW
肌醇1,4,5-三磷酸[InsP3(1,4,5)]是可兴奋和不可兴奋细胞中调节Ca2+信号的主要第二信使。InsP3（1,4,5）通过磷酸化和去磷酸化步骤网络被广泛代谢为具有潜在第二信使功能的产物。肌醇1,3,4,5-四聚磷酸[InsP4(1,3,4,5)]是InsP3（1,4,5）的直接代谢物，也与Ca2+信号传导有关，但目前尚不清楚InsP4（1,3,4,5）是与InsP3（1,4,5）联合起作用，还是直接和独立调节Ca2+信号传导，特别是在神经元中。我们报道了龙虾（Panulirus argus）的嗅觉受体神经元在质膜上表达一个InsP4（1,3,4,5）受体，这是一个功能通道。该通道在电导、动力学和电压敏感性方面不同于先前报道的两个质膜InsP3（1,4,5）门控通道。在接近的空间中，InsP4（1,3,4,5）和InsP3（1,4,5）门控通道相互作用，改变通道的打开概率，这可能是调节Ca2+进入神经元的新机制。
Inositol 1,4,5-trisphosphate [InsP3(1,4,5)] is a major second messenger regulating Ca2+ signaling in excitable and nonexcitable cells. InsP3(1,4,5) is extensively metabolized through a network of phosphorylation and dephosphorylation steps to products with potential second messenger function. Inositol 1,3,4,5-tetrakisphosphate [InsP4(1,3,4,5)], the direct metabolite of InsP3(1,4,5), has also been associated with Ca2+ signaling, but whether InsP4(1,3,4,5) acts in combination with InsP3(1,4,5) or whether it regulates Ca2+ signaling directly and independently is unclear, particularly in neurons. We report that olfactory receptor neurons in the lobster (Panulirus argus) express an InsP4(1,3,4,5) receptor in the plasma membrane that is a functional channel. The channel differs in conductance, kinetics, and voltage sensitivity from two plasma membrane InsP3(1,4,5)-gated channels previously reported in these neurons. In close spatial proximity, the InsP4(1,3,4,5)-and InsP3(1,4,5)-gated channels interact reciprocally to alter the channels' open probabilities in what may be a novel mechanism for regulating Ca2+ entry in neurons.