The First Case of Ischemia-Free Kidney Transplantation in Humans
The First Case of Ischemia-Free Kidney Transplantation in Humans
复制标题
第一例人类无缺血肾移植
DOI：
10.3389/fmed.2019.00276
复制
发表时间：
2019-12-11
影响因子：
3.9
通讯作者：
Guo, Zhiyong
中科院分区：
文献类型：
--
作者：
He, Xiaoshun;Chen, Guodong;Guo, Zhiyong
背景资料：自1954年第一例肾移植成功以来，缺血再灌注损伤（IRI）一直被认为是器官移植中不可避免的事件。为了避免IRI，我们已经建立了一种新的程序称为无缺血器官移植。在这里，我们描述了第一例缺血性肾移植（IFKT）。材料与方法：移植肾由一位19岁的脑死亡供体捐献。接受者是一名患有终末期糖尿病肾病的47岁男性。移植物的采购，保存和植入没有停止血液供应使用常温机器灌注。结果：移植肾的外观、灌注流量和尿量表明整个手术过程中肾功能良好。肌酐在移植后3天内迅速下降至正常范围。移植后血清肾损伤标志物水平较低。未发生排斥反应或血管或感染并发症。患者顺利恢复。结论：这篇论文标志着人类IFKT的第一例。这一创新可能为优化肾移植的移植结果提供独特的解决方案。
Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.