Mechanism of blocking by hyperimmune serum of lymphocyte-mediated cytolysis of allogeneic tumor cells.
Mechanism of blocking by hyperimmune serum of lymphocyte-mediated cytolysis of allogeneic tumor cells.
复制标题
超免疫血清阻断淋巴细胞介导的同种异体肿瘤细胞细胞溶解作用的机制。
作者：
R. Todd;R. Stulting;G. Berke
我们在体外研究了阻断抗血清抑制淋巴细胞介导的异基因肿瘤细胞溶解的机制。这种分析是由于我们以前观察到细胞溶解反应可以实验地分为结合相和裂解相。结果直接表明，抑制淋巴细胞介导的细胞溶解可归因于防止异基因肿瘤细胞与细胞毒性淋巴细胞结合。阻断抗血清也可能通过在肿瘤细胞不可逆损伤之前将结合的淋巴细胞从肿瘤细胞中移出而抑制细胞溶解。
Summary We have investigated the mechanism by which blocking antiserum inhibits lymphocyte-mediated cytolysis of allogeneic tumor cells in vitro. This analysis was made possible by our previous observation that the cytolytic reaction can be experimentally separated into binding and lytic phases. The results show directly that inhibition of lymphocyte-mediated cytolysis can be attributed to prevention of allogeneic tumor cell binding by cytotoxic lymphocytes. Blocking antiserum may also inhibit cytolysis by displacing bound lymphocytes from tumor cells prior to irreversible tumor cell damage.