The promise of organ and tissue preservation to transform medicine.
The promise of organ and tissue preservation to transform medicine.
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DOI：
10.1038/nbt.3889
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发表时间：
2017-06-07
影响因子：
46.9
通讯作者：
Toner M
中科院分区：
文献类型：
--
作者：
Giwa S;Lewis JK;Alvarez L;Langer R;Roth AE;Church GM;Markmann JF;Sachs DH;Chandraker A;Wertheim JA;Rothblatt M;Boyden ES;Eidbo E;Lee WPA;Pomahac B;Brandacher G;Weinstock DM;Elliott G;Nelson D;Acker JP;Uygun K;Schmalz B;Weegman BP;Tocchio A;Fahy GM;Storey KB;Rubinsky B;Bischof J;Elliott JAW;Woodruff TK;Morris GJ;Demirci U;Brockbank KGM;Woods EJ;Ben RN;Baust JG;Gao D;Fuller B;Rabin Y;Kravitz DC;Taylor MJ;Toner M
按需更换器官和组织的能力每年可以挽救或改善全球数百万人的生命，并创造与治愈癌症同等的公共健康效益。器官和组织保存的未满足需求给移植、再生医学、药物发现以及生物医学等各种快速发展的领域带来了巨大的后勤限制。越来越多的研究人员、临床医生、倡导组织、学术机构和其他利益相关者组成的联盟已经聚集在一起，以解决保护进展方面未得到满足的需求，概述仍然存在的挑战，并确定投资不足和未开发机会的领域。与此同时，最近的发现为围绕生物保护的一系列研究领域的突破提供了原理证明。这些发展表明，整合多种现有保护方法和过去十年蓬勃发展的新技术的新范式可以改变保护研究。利用这些机会需要许多研究领域和利益相关群体的参与。需要协调一致的努力来加快保存进展，从而改变医学和医学科学的多个领域。
The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.