Update of the reference and HBM values derived by the German Human Biomonitoring Commission
Update of the reference and HBM values derived by the German Human Biomonitoring Commission
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DOI：
10.1016/j.ijheh.2011.06.007
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发表时间：
2011-12-01
影响因子：
6
通讯作者：
Kolossa-Gehring, Marike
中科院分区：
文献类型：
--
作者：
Schulz, Christine;Wilhelm, Michael;Kolossa-Gehring, Marike
2007年，我们回顾了德国人体生物监测委员会的工作原理和工作程序，以及到那时为止得出的参考值和人体生物监测（HBM）值。从那时起，委员会决定根据每日可耐受摄入量推导出额外的HBM I值，并对尿液中邻苯二甲酸2-乙基己基酯（DEHP）的代谢物使用和评估了这种新方法。此外，委员会还推导出了尿中铊的HBM I值，重新确定了血液中铅的HBM值，并更新了尿中镉的HBM值。根据2003年至2006年德国儿童环境调查（GerES IV）的代表性数据，委员会更新了德国儿童尿液和血液中大量环境污染物的参考值。自2007年以来，食典委已推导出人类血浆中全氟辛烷磺酸和全氟辛酸、尿液中铊、尿液中芳香胺、尿液中大量邻苯二甲酸酯代谢物以及人类母乳中有机氯农药的新的和更新的参考值。此外，食典委还评估了一般人群中两种萘代谢物和丙烯酰胺（使用丙烯酰胺-血红蛋白加合物）的背景接触水平。本文件报告了新的数值，包括已经公布的数值，以便提供最新的概览。(C)2011年Elsevier GmbH。All rights reserved.
In 2007, we reviewed the working principles and working procedures of the German Human Biomonitoring Commission together with the reference values and human biomonitoring (HBM) values derived up to that time. Since then, the Commission has decided to derive additionally HBM I values on the basis of tolerable daily intakes and has used and evaluated this new approach on the metabolites of (2-ethylhexyl) phthalate (DEHP) in urine. Furthermore, the Commission has derived a HBM I value for thallium in urine, has recinded the HBM values for lead in blood, and has updated the HBM values for cadmium in urine. Based on the representative data of the German Environmental Survey on Children from 2003 to 2006 (GerES IV), the Commission has updated the reference values for a large number of environmental pollutants in urine and blood of children in Germany. Since 2007, the Commission has derived new and updated reference values for PFOS and PFOA in human plasma, for thallium in urine, for aromatic amines in urine, for a comprehensive number of phthalate metabolites in urine, and for organochlorine pesticides in human breast milk. Furthermore, the Commission has evaluated background exposure levels for two naphthalene metabolites and acrylamide (using acrylamide-haemoglobin adduct) for the general population. This paper reports the new values, including those already published, in order to provide an updated overview. (C) 2011 Elsevier GmbH. All rights reserved.