EFFECT OF CHRONIC INTRA-ACCUMBENS ADMINISTRATION OF THE TRH ANALOG CG3509 ON HISTAMINE-INDUCED BEHAVIOR IN THE RAT
EFFECT OF CHRONIC INTRA-ACCUMBENS ADMINISTRATION OF THE TRH ANALOG CG3509 ON HISTAMINE-INDUCED BEHAVIOR IN THE RAT
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DOI：
10.1111/j.1476-5381.1989.tb12012.x
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发表时间：
1989-07-01
影响因子：
7.3
通讯作者：
BENNETT, GW
中科院分区：
文献类型：
--
作者：
BRISTOW, LJ;BENNETT, GW
本研究探讨了促甲状腺激素释放激素（TRH）类似物CG 3509的慢性内给药对CG 3509和组胺诱导的大鼠自发运动活动和脑TRH样免疫反应（TRH-LI）水平的影响。慢性伏隔内给予CG 3509（5 ×5 μ g，持续3天）诱导：（a）组胺内CG 3509（0.5 μ g）诱导的活动过度显著（P < 0.05）减少，（B）丘脑核中TRH-LI水平降低，但其它脑区域没有，（c）组胺诱导的非运动性活动过度显著增加（107%P < 0.01）。本研究结果表明，改变中央TRH功能的TRH类似物治疗后，增强了行为多动症的作用，可能通过H1受体的变化，并建议神经肽，TRH和组胺在大鼠大脑中的行为唤醒机制的相互作用。
The present study has investigated the effect of chronic intra-accumbens administration of the thyrotrophin-releasing hormone (TRH) analogue, CG3509, on CG3509- and histamine-induced spontaneous motor activity and brain TRH-like immunoreactive (TRH-LI) levels n the rat. Chronic intra-accumbens administration of CG3509 (5 .times. 5 .mu.g over 3 days) induced: (a) a significant (P < 0.05) reduction in intra-accumbens CG3509 (0.5 .mu.g)-induced hyperactivity, (b) reduced levels of TRH-LI in the nucleus accumbens but not other brain regions, (c) a marked increase (107% P < 0.01) in histamine-induced non-locomotor hyperactivity. The present results demonstrate that alteration of central TRH function following treatment with a TRH analogue enhances the effect of intra-accumbens histamine on behavioural hyperactivity, possibly via changes in H1 receptors and suggest that the neuropeptide, TRH and histamine interact in behavioural arousal mechanisms in rat brain.