Residential Exposure to Urban Air Pollution, Ankle-Brachial Index, and Peripheral Arterial Disease
Residential Exposure to Urban Air Pollution, Ankle-Brachial Index, and Peripheral Arterial Disease
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DOI：
10.1097/ede.0b013e3181961ac2
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发表时间：
2009-03-01
期刊：
影响因子：
5.4
通讯作者：
Joeckel, Karl-Heinz
中科院分区：
文献类型：
--
作者：
Hoffmann, Barbara;Moebus, Susanne;Joeckel, Karl-Heinz
背景：长期暴露于颗粒空气污染与心血管疾病的增加有关。这种关联的生物学途径还没有完全understood.Methods：我们研究了城市空气污染与外周血管床动脉粥样硬化的关联，使用基线数据（2000-2003年）从4348名参与者在德国鲁尔区的一项以人口为基础的队列研究。每年细颗粒物（PM2.5）的暴露水平，来自分散和化学运输模型，被分配到参与者的家庭地址。住宅交通暴露评估住宅和主要道路（联邦和州公路）之间的距离。使用多元回归分析和控制个体水平的危险因素，我们检查了PM2.5和交通与踝臂指数和外周动脉疾病患病率的关系，定义为指数小于0.9或有外周动脉疾病治疗史。结果：居住在主干道101-200、51-100和50英寸范围内的人，踝臂指数的校正绝对下降值为-0.015（95%置信区间[CI] = -0.030至0.0）、-0.002（-0.021至0.016）和-0.024（-0.047至0.001）。在女性中发现了更强的关联，而在男性中没有发现明显的关联。与居住在200米以外的人相比，居住在主要道路50英寸以内的人患外周动脉疾病的OR为1.77（1.01-2.1）。与PM2.5的关联是不一致的。结论：这项研究增加了长期居住暴露于交通与动脉粥样硬化的证据。
Background: Long-term exposure to particulate air pollution has been associated with increased cardiovascular disease. Biologic pathways for this association are not fully understood.Methods: We examined the association of urban air pollution with atherosclerosis of the peripheral vascular bed, using baseline data (2000-2003) from 4348 participants in a population-based cohort study in the German Ruhr Area. Levels of annual fine particulate matter (PM2.5) exposure, derived from a dispersion and chemistry transport model, were assigned to the participants' home addresses. Residential traffic exposure was assessed by the distance between residence and major roads (federal and state highways). Using multiple regression analyses and controlling for individual level risk factors, we examined the association of PM2.5 and traffic with the ankle-brachial index and prevalence of peripheral arterial disease, defined as an index of less than 0.9 or a history of treatment for peripheral artery disease.Results: Living within 101-200, 51-100, and 50 in of a major road was associated with an adjusted absolute decrease in ankle-brachial index of -0.015 (95% confidence interval [CI] = -0.030 to 0.0), -0.002 (-0.021 to 0.016) and -0.024 (-0.047 to -0.001), respectively. Stronger associations were seen in women, whereas no clear association was found in men. Individuals living within 50 in of a major road had an OR of 1.77 (1.01-2.1) for peripheral arterial disease compared with those living more than 200 m away. Associations with PM2.5 were inconsistent.Conclusions: This study adds to the evidence that long-term residential exposure to traffic is associated with atherosclerosis.