Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.
Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.
复制标题
演示高胆红素血症新生儿血清中胆红素-IX α 的几何异构体以及黄疸光疗的机制。
作者：
S. Onishi;K. Isobe;S. Itoh;N. Kawade;S. Sugiyama
首次通过反相高压液相色谱法证实了高胆红素血症新生儿血清中的光胆红素-IX α。在光疗过程中浓度显著增加。与血清中的这些变化相对应，胆汁中未结合胆红素浓度显著增加，但在胆汁中未检测到光胆红素-IX α。此外，在光疗过程中，胆汁中出现了大量重氮阴性的“未知色素”。
Photobilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant was demonstrated for the first time by reversed-phase high-pressure liquid chromatography. The concentrations increased significantly during phototherapy. Corresponding to these changes in the serum, biliary unconjugated bilirubin concentrations increased markedly but photobilirubin-IX alpha was not detected in the bile. Moreover, large amounts of 'unknown pigment' that are diazo-negative appeared in the bile during phototherapy.