Histamine and deep brain stimulation: the pharmacology of regularizing a brain.
Histamine and deep brain stimulation: the pharmacology of regularizing a brain.
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DOI：
10.1172/jci124777
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Timothy C. Whalen;A. Gittis
中科院分区：
文献类型：
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作者：
Timothy C. Whalen;A. Gittis
帕金森病(PD)患者的基底节中组胺含量增加，但这种神经递质在PD中的作用尚不清楚。在这一期的JCI中，庄等人。证明丘脑底核(STN)中的组胺水平上升，以补偿异常的放电模式。将组胺注射到STN可以恢复正常的放电模式和运动活动，而仅仅改变放电频率并不会对行为产生影响。此外，STN脑深部刺激是一种治疗帕金森病的广泛疗法，它通过内源性组胺释放来调节放电。这表明，引起帕金森病症状的是异常的放电模式，而不是心率，这种组胺能途径可能会导致治疗这种疾病的新方法。
Parkinson's disease (PD) patients have increased histamine in their basal ganglia, but the role of this neurotransmitter in PD is poorly understood. In this issue of the JCI, Zhuang et al. demonstrate that histamine levels rise in the subthalamic nucleus (STN) to compensate for abnormal firing patterns. Injection of histamine into the STN restores normal firing patterns and motor activity, whereas merely changing firing rates has no behavioral effect. Moreover, STN deep brain stimulation, a widespread therapy for PD, regularizes firing through endogenous histamine release. This suggests that abnormal firing patterns, rather than rates, cause PD symptoms, and this histaminergic pathway may lead to new treatments for the disease.