Multi-Therapeutic Potential of Naringenin (4',5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms.
Multi-Therapeutic Potential of Naringenin (4',5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms.
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DOI：
10.3390/plants9121784
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发表时间：
2020-12-16
期刊：
影响因子：
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通讯作者：
Almatroudi NM
中科院分区：
文献类型：
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作者：
Arafah A;Rehman MU;Mir TM;Wali AF;Ali R;Qamar W;Khan R;Ahmad A;Aga SS;Alqahtani S;Almatroudi NM
在过去的几十年里进行了广泛的研究，提供了数千种已发现的植物化学物质及其生物活性的详细说明，这些化学物质有可能被开发用于各种各样的药用目的。这些植物化学物质主要由多酚类组成，其次是萜类和生物碱，在药理学上对临床应用具有重要意义。有许多已发表的报告表明，植物化学物质的主要作用已被证明具有治疗几种疾病的潜力。然而，并不是所有的植物化学物质都具有重要的药用特性，只有一些植物化学物质表现出可行的生物效应。柚皮素是一种在柑橘类水果中发现的黄酮，可以提高免疫力，修复DNA损伤，清除自由基。尽管柚皮素的生物利用度很低，但已知它具有多种有前景的药用生物学特性，包括抗炎和抗氧化活性。本文综述了柚皮素的理化、药代动力学和药效学等方面的研究进展。此外，还讨论了柚皮素的抗癌、降糖、保肝、保神经、保心、保肾、保胃等药理作用及其作用机制。
Extensive research has been carried out during the last few decades, providing a detailed account of thousands of discovered phytochemicals and their biological activities that have the potential to be exploited for a wide variety of medicinal purposes. These phytochemicals, which are pharmacologically important for clinical use, primarily consist of polyphenols, followed by terpenoids and alkaloids. There are numerous published reports indicating the primary role of phytochemicals proven to possess therapeutic potential against several diseases. However, not all phytochemicals possess significant medicinal properties, and only some of them exhibit viable biological effects. Naringenin, a flavanone found in citrus fruits, is known to improve immunity, repair DNA damage, and scavenge free radicals. Despite the very low bioavailability of naringenin, it is known to exhibit various promising biological properties of medicinal importance, including anti-inflammatory and antioxidant activities. This review focuses on the various aspects related to naringenin, particularly its physicochemical, pharmacokinetic, and pharmacodynamic properties. Furthermore, various pharmacological activities of naringenin, such as anticancer, antidiabetic, hepatoprotective, neuroprotective, cardioprotective, nephroprotective, and gastroprotective effects, have been discussed along with their mechanisms of action.