Novel Atom Transfer Radical Polymerization Method to Yield Copper-Free Block Copolymeric Biomaterials
Novel Atom Transfer Radical Polymerization Method to Yield Copper-Free Block Copolymeric Biomaterials
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DOI：
10.1002/macp.201300034
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发表时间：
2013-06-25
影响因子：
2.5
通讯作者：
Mallapragada, Surya K.
中科院分区：
文献类型：
--
作者：
Adams, Justin R.;Mallapragada, Surya K.
报道了一种新的用于原子转移自由基聚合（ATRP）的催化剂，用于合成无铜的聚（2-二乙基氨基乙基甲基丙烯酸酯（PDEAEM）基五嵌段共聚物生物材料，该材料已被证明是有效的基因递送载体。由于残留的可溶性铜盐用作催化剂，随着功能聚合物在药物和基因递送方面的潜在应用不断增长，生物相容性日益受到关注。报道的ATRP合成方法利用新型氧化铜（I）纳米颗粒作为催化剂，其在聚合后可以容易地去除，X射线光谱（XPS）显示最终产物中没有残留的铜。
A new catalyst is reported for atom transfer radical polymerization (ATRP) for the synthesis of copper-free poly(2-diethylaminoethyl methacrylate (PDEAEM)-based pentablock copolymeric biomaterials that have been shown to be effective gene delivery vectors. Biocompatibility is an increasing concern with growing applications for functional polymers with potential applications in drug and gene delivery, because of the residual soluble copper salts used as catalysts. The reported ATRP synthesis method utilizes novel copper(I) oxide nanoparticles as catalysts that can be easily removed after polymerization, with X-ray spectroscopy (XPS) showing no residual copper in the final product.