Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography.
Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography.
复制标题
通过磁共振成像对区域心肌充氧的定量：正电子发射断层扫描验证。
DOI：
10.1161/circimaging.109.897546
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
McCommis KS;Goldstein TA;Abendschein DR;Herrero P;Misselwitz B;Gropler RJ;Zheng J
心肌缺血的综合评价需要测量氧供应和需求。正电子发射断层扫描（PET）目前是此类评估的黄金标准，但由于其电离辐射、有限的可用性和高成本，其使用受到限制。心脏磁共振成像（MRI）的方法来评估心肌氧合。本研究的目的是在冠状动脉狭窄犬模型中评价和验证该技术与PET在药理学应激期间的比较。21只无冠状动脉狭窄（对照组）或中度至重度急性冠状动脉狭窄的比格犬和小型杂种犬在静息时和潘生丁血管舒张或多巴酚丁胺应激期间接受MRI和PET成像，以诱导心脏灌注和氧合的广泛变化。MRI首过灌注成像定量心肌血流量（MBF）和容积（MBV）。采用MRI血氧水平依赖性（BOLD）技术测定药物性充血时心肌氧摄取分数（OEF）。心肌耗氧量（MVO 2）按Fick定律测定。在相同的狗中，15 O-水和11 C-乙酸分别用于通过PET测量MBF和MVO 2。对MR和PET进行了区域评估。MRI数据与MBF（R2 = 0.79，P < 0.001）、MVO 2（R2 = 0.74，P < 0.001）和OEF（R2 = 0.66，P < 0.01）的PET值具有良好的相关性。心脏MRI方法可以提供一种替代放射性核素成像在心肌缺血的设置。我们新开发的定量MRI氧合成像技术可能是一种有价值的非侵入性工具，直接评估心肌能量和效率。
A comprehensive evaluation of myocardial ischemia requires measures of both oxygen supply and demand. Positron emission tomography (PET) is currently the gold standard for such evaluations, but its use is limited due to its ionizing radiation, limited availability, and high cost. A cardiac magnetic resonance imaging (MRI) method was developed for assessing myocardial oxygenation. The purpose of this study was to evaluate and validate this technique compared to PET during pharmacologic stress in a canine model of coronary artery stenosis. Twenty-one beagles and small mongrel dogs without coronary artery stenosis (controls), or with moderate to severe acute coronary artery stenosis underwent MRI and PET imaging at rest and during dipyridamole vasodilation or dobutamine stress to induce a wide range of changes in cardiac perfusion and oxygenation. MRI first-pass perfusion imaging was performed to quantify myocardial blood flow (MBF) and volume (MBV). The MRI blood-oxygen-level-dependent (BOLD) technique was used to determine the myocardial oxygen extraction fraction (OEF) during pharmacologic hyperemia. Myocardial oxygen consumption (MVO2) was determined by Fick’s law. In the same dogs, 15O-water and 11C-acetate were used to measure MBF and MVO2, respectively, by PET. Regional assessments were performed for both MR and PET. MRI data correlated nicely with PET values for MBF (R2 = 0.79, P < 0.001), MVO2 (R2 = 0.74, P < 0.001), and OEF (R2 = 0.66, P < 0.01). Cardiac MRI methods may provide an alternative to radionuclide imaging in settings of myocardial ischemia. Our newly developed quantitative MRI oxygenation imaging technique may be a valuable non-invasive tool to directly evaluate myocardial energetics and efficiency.