Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007-2015
Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007-2015
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DOI：
10.3390/ijerph16193720
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发表时间：
2019-10-01
影响因子：
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通讯作者：
Crooks, James L.
中科院分区：
文献类型：
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作者：
Abdo, Mona;Ward, Isabella;Crooks, James L.
科罗拉多州经常受到逆风地区野火烟雾远距离输送的影响。这种烟雾是环境PM2.5的主要来源。尽管最近才对野火烟雾的影响进行了调查，但孕妇在怀孕期间暴露于PM2.5总量与出生体重下降和其他不良后果有关。本研究的目的是估计不良妊娠结局与周围野火烟雾PM2.5之间的关系。野火烟雾PM2.5暴露量使用先前发表的方法，结合地面监测和遥感数据进行估算。采用邮政编码分层的逻辑回归模型和邮政编码随机截距混合模型来检验关联性。研究的主要结局是早产和出生体重。次要结局包括妊娠期高血压、妊娠期糖尿病、新生儿重症监护病房入院、辅助通气、胎龄小和低出生体重。在整个妊娠期和妊娠中期暴露于野火烟雾PM2.5与早产呈正相关(OR = 1.076 (μ g/m(3))(-1)) [95% CI = 1.016, 1.139；p = 0.013)和1.132(μg / m (3)) (1) (95% CI = 1.088, 1.178);p < 0.0001)，而妊娠早期暴露与出生体重下降有关(-5.7 g/(mu g/m(3)) [95% CI: -11.1, -0.4；P = 0.036])。次要结果好坏参半。
Colorado is regularly impacted by long-range transport of wildfire smoke from upwind regions. This smoke is a major source of ambient PM2.5. Maternal exposure to total PM2.5 during pregnancy has been linked to decreased birth weight and other adverse outcomes, although the impact of wildfire smoke contribution has only recently been investigated. The objective of this study was to estimate associations between adverse pregnancy outcomes and ambient wildfire smoke PM2.5. Wildfire smoke PM2.5 exposures were estimated using a previously published method incorporating ground-based monitors and remote sensing data. Logistic regression models stratified by ZIP code and mixed models with random intercept by ZIP code were used to test for associations. The primary outcomes of interest were preterm birth and birth weight. Secondary outcomes included gestational hypertension, gestational diabetes, neonatal intensive care unit admission, assisted ventilation, small for gestational age, and low birth weight. Exposure to wildfire smoke PM2.5 over the full gestation and during the second trimester were positively associated with pre-term birth (OR = 1.076 (mu g/m(3))(-1) [95% CI = 1.016, 1.139; p = 0.013] and 1.132 (mu g/m(3))(-1) [95% CI = 1.088, 1.178]; p < 0.0001, respectively), while exposure during the first trimester was associated with decreased birth weight (-5.7 g/(mu g/m(3)) [95% CI: -11.1, -0.4; p = 0.036]). Secondary outcomes were mixed.