Myogenic Tumors in Children and Adolescents
Myogenic Tumors in Children and Adolescents
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DOI：
10.2350/10-12-0953-pb.1
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发表时间：
2012-01-01
影响因子：
1.9
通讯作者：
Coffin, Cheryl M.
中科院分区：
文献类型：
--
作者：
Parham, David M.;Alaggio, Rita;Coffin, Cheryl M.
儿童横纹肌和平滑肌肿瘤是一组不同的肿瘤，与成人肿瘤相比有一些独特的方面。横纹肌肉瘤是婴儿和儿童最常见的软组织肉瘤，在青少年中相对常见。相反，平滑肌肿瘤相对罕见，各种类型的横纹肌瘤和平滑肌和骨骼肌错构瘤非常罕见。近年来，通过免疫组织化学、细胞遗传学或分子遗传学分析等辅助技术，对横纹肌肉瘤的病理和遗传方面的认识得到了加强。横纹肌肉瘤目前的分类强调组织学与预后的相关性。本文综述了横纹肌和平滑肌肿瘤的临床病理特征，重点是这些肿瘤在儿童和青少年的独特方面和鉴别诊断。
Neoplasms of striated and smooth muscle in children are a diverse group of neoplasms that have some unique aspects in contrast to these tumors in adults. Rhabdomyosarcoma is the most common soft tissue sarcoma of infancy and childhood and is relatively common in adolescents. In contrast, smooth muscle tumors are relatively rare, and the various types of rhabdomyoma and smooth and skeletal muscle hamartomas are very uncommon. In recent years, the understanding of the pathologic and genetic aspects of rhabdomyosarcoma has been enhanced by adjunct techniques, such as immunohistochemistry and cytogenetic or molecular genetic analysis. The current classification of rhabdomyosarcoma emphasizes the histologic-prognostic correlations. This article reviews the clinicopathologic features of striated and smooth muscle tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents and the differential diagnosis.