Cultivation and characterization of three strains of murine rotavirus
Cultivation and characterization of three strains of murine rotavirus
复制标题
三株鼠轮状病毒的培养和鉴定
作者：
H. Greenberg;P. Vo;R. Jones
三种不同的小鼠轮状病毒株适应在细胞培养中生长。这些菌株在基因上是相关的，但不完全相同；它们是血清型异质性的。与异源猿猴轮状病毒相比，可培养的病毒株对乳鼠的传染性显著更强(约10(6)倍)。同源的小鼠轮状病毒株从接种的小鼠传播到未接种的小鼠，并导致腹泻，而异种轮状病毒不会传播并导致疾病。
Three distinct strains of murine rotavirus were adapted to growth in cell culture. These strains are genetically related but not identical; they are serotypically heterogeneous. The cultivatable strains were substantially more infectious (approximately 10(6)-fold) for suckling mice than heterologous simian rotaviruses were. Homologous murine rotavirus strains spread from inoculated to uninoculated litter mates and caused diarrhea, while heterologous rotaviruses did not spread and cause illness.