Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.
Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.
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DOI：
10.1016/j.autneu.2011.12.004
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发表时间：
2012-04-03
期刊：
影响因子：
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通讯作者：
Santana-Filho VJ
中科院分区：
文献类型：
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作者：
Oliveira LR;de Melo VU;Macedo FN;Barreto AS;Badaue-Passos D Jr;Viana dos Santos MR;Dias DP;Sluka KA;DeSantana JM;Santana-Filho VJ
纤维肌痛（FM）的特征是慢性非炎性广泛性疼痛（CWP）和交感神经功能的变化。为了阐明FM的病理生理机制，我们使用了一个完善的CWP动物模型。我们的目的是评估CWP诱导大鼠心脏自主神经平衡和压力反射功能的变化。通过向左腓肠肌中间隔5天两次注射酸性盐水（pH 4.0，n = 8）诱导CWP。对照组动物注射生理盐水（pH 7.2，n = 6）两次。第二次注射酸性生理盐水或生理盐水后1天，动物进行脉搏间期（PI）和收缩期动脉压（SAP）变异性和自发压力反射敏感性（BRS）评价。诱导CWP后，PI谱的低频（LF）带功率增加（12.75 ± 1.04 nu），高频（HF）带减少（87.25 ± 1.04 nu）和LF/HF比值增加（0.16 ± 0.01），与对照动物（7.83 ± 1.13 nu LF; 92.16 ± 1.13 nu HF; 0.08 ± 0.01 LF/HF）相比。此外，与对照动物（2.97 ± 0.61 mmHg 2）相比，SAP频谱的LF带功率（7.93 ± 1.39 mmHg 2）增加。与对照动物（0.71 ± 0.03 ms/mmHg）相比，酸性盐水注射大鼠的BRS较低（0.59 ± 0.06 ms/mmHg）。我们的研究结果表明，在大鼠中诱导CWP使心脏交感迷走神经平衡向交感神经优势转移，并降低BRS。这些数据证实了人类FM的发现。
Fibromyalgia (FM) is characterized by chronic non-inflammatory widespread pain (CWP) and changes in sympathetic function. In attempt to elucidate the pathophysiological mechanisms of FM we used a well-established CWP animal model. We aimed to evaluate changes in cardiac autonomic balance and baroreflex function in response to CWP induction in rats. CWP was induced by two injections of acidic saline (pH 4.0, n=8) five days apart into the left gastrocnemius muscle. Control animals were injected twice with normal saline (pH 7.2, n=6). One day after the second injection of acidic saline or normal saline, the animals had pulse interval (PI) and systolic arterial pressure (SAP) variability, and spontaneous baroreflex sensitivity (BRS) evaluated. After induction of CWP, there was an increase of power in the low frequency (LF) band of PI spectrum (12.75 ± 1.04 nu), a decrease in the high frequency (HF) band (87.25 ± 1.04 nu) and an increase of LF/HF ratio (0.16 ± 0.01), when compared to control animals (7.83 ± 1.13 nu LF; 92.16 ± 1.13 nu HF; 0.08 ± 0.01 LF/HF). In addition, there was an increase of power in the LF band of SAP spectrum (7.93 ± 1.39 mmHg2) when compared to control animals (2.97 ± 0.61 mmHg2). BRS was lower in acidic saline injected rats (0.59 ± 0.06 ms/mmHg) when compared to control animals (0.71 ± 0.03 ms/mmHg). Our results showed that induction of CWP in rats shifts cardiac sympathovagal balance towards sympathetic predominance and decreases BRS. These data corroborate findings in humans with FM.