Signalling Through the RhoGEF Pebble in Drosophila
Signalling Through the RhoGEF Pebble in Drosophila
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DOI：
10.1002/iub.310
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发表时间：
2010-04-01
期刊：
影响因子：
4.6
通讯作者：
Saint, Robert
中科院分区：
文献类型：
--
作者：
Gregory, Stephen L.;Lorensuhewa, Nirmal;Saint, Robert
Ras超家族的小GTPase通路涉及动物细胞的广泛信号传导过程。小的gtpase通过充当分子开关来控制通路。它们通过GTP交换因子（gef）从非活性的gdp结合形式转化为活性的GTP结合形式。gef的时空调控是小GTPases调控的重要组成部分。在这里，我们回顾了果蝇RhoGEF， Pebble（哺乳动物ECT2的果蝇同源物）的作用。我们讨论了它在细胞质分裂和细胞迁移中的作用，强调了Rho家族信号通路在生物系统中运作的多样性。(C) 2010 [j] .中国生物医学工程学报，32 (4):299 - 299,2010
Small GTPase pathways of the Ras superfamily are implicated in a wide range of signalling processes in animal cells. Small GTPases control pathways by acting as molecular switches. They are converted from an inactive GDP-bound form to an active GTP-bound form by GTP exchange factors (GEFs). The spatial and temporal regulation of GEFs is a major component of the regulation of small GTPases. Here we review the role of the Drosophila RhoGEF, Pebble (the Drosophila ortholog of mammalian ECT2). We discuss its roles in cytokinesis and cell migration, highlighting the diversity with which Rho family signalling pathways operate in biological systems. (C) 2010 IUBMB IUBMB Life, 62(4): 290-295, 2010