Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain.
Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain.
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大鼠脑中多巴胺（DA-2 和 DA-3）受体位点分布的应变差异。
DOI：
10.1016/j.lfs.2006.02.030
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Tejani-Butt,Shanaz
中科院分区：
文献类型：
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作者：
Yaroslavsky,Irene;Colletti,Michael;Jiao,Xilu;Tejani-Butt,Shanaz
多巴胺（DA）通路介导了许多神经元功能，这些功能与精神疾病有关。以前，我们的实验室调查了多巴胺转运蛋白在维斯塔-京都大鼠，一个所谓的抑郁行为的啮齿动物模型的状态，并报告了显着改变转运蛋白结合位点在几个大脑区域相比，控制大鼠品系。鉴于DA-2和DA-3受体属于同一类DA受体，共同定位于中脑边缘和黑质纹状体区域的大脑和功能的自受体，本研究绘制了中央DA-2和DA-3受体在Wistar-Kyoto和Wistar大鼠的分布。结果表明，与Wistar大鼠相比，125 I-磺必利与DA-2受体的结合在中脑核（壳）和腹侧被盖区较高，而在中脑核（核）、尾壳核和下丘脑较低。相比之下，125 I-磺必利与DA-3受体的结合率在Wistar-Kyoto大鼠的尾壳核、延髓核（壳和核）和Calleja岛中高于Wistar大鼠。考虑到腹侧被盖区的DA-2样受体作为自身受体发挥作用，在Wistar-Kyoto大鼠中，DA-2和DA-3受体发挥的更大抑制作用可能导致接受该细胞体区域投射的区域中DA水平的净不足。
The dopamine (DA) pathway mediates numerous neuronal functions which are implicated in psychiatric disorders. Previously, our lab investigated the status of the dopamine transporter in the Wistar–Kyoto rat, a purported rodent model of depressive behavior, and reported significant alterations in transporter binding sites in several brain regions when compared to control rat strains. Given that DA-2 and DA-3 receptors belong to the same class of DA receptors, are co-localized in the mesolimbic and nigrostriatal regions of the brain and function as autoreceptors, this study mapped the distribution of central DA-2 and DA-3 receptors in Wistar–Kyoto and Wistar rats. The results indicated that while the binding of125I-sulpride to DA-2 receptors was higher in the nucleus accumbens (shell) and ventral tegmental area, it was lower in the nucleus accumbens (core), caudate putamen and hypothalamus in Wistar–Kyoto compared to Wistar rats. In contrast, the binding of125I-sulpride to DA-3 receptors was higher in the caudate putamen, nucleus accumbens (shell and core) and islands of Calleja in Wistar–Kyoto compared to Wistar rats. Given that DA-2 like receptors in the ventral tegmental area function as autoreceptors, it is possible that the greater inhibitory effects exerted by DA-2 and DA-3 receptors in Wistar–Kyoto rats may lead to a net deficit in DA levels in areas receiving projection from this cell body area.