Drosophila STING protein has a role in lipid metabolism.
Drosophila STING protein has a role in lipid metabolism.
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果蝇STING蛋白在脂质代谢中具有作用。
DOI：
10.7554/elife.67358
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发表时间：
2021-09-01
期刊：
影响因子：
7.7
通讯作者：
Chesnokov I
中科院分区：
文献类型：
--
作者：
Akhmetova K;Balasov M;Chesnokov I
干扰素基因刺激因子（Stimulator of interferon genes，STING）通过控制I型干扰素对入侵病原体的应答，在天然免疫中发挥重要作用。在这项工作中，我们描述了一个以前未知的作用STING在果蝇的脂质代谢。STING缺失的果蝇对饥饿和氧化应激敏感，脂质储存减少，脂质代谢基因表达下调。我们发现果蝇STING与脂质合成酶乙酰辅酶A羧化酶（ACC）和脂肪酸合成酶（FATCH）相互作用。ACC和Festival也相互作用，这表明所有三种蛋白质可能是一个大的多酶复合物的组成部分。果蝇STING的缺失导致ACC定位紊乱和FcB酶活性降低。总之，我们的研究结果证明了STING在果蝇脂质代谢中的一种以前未描述的作用。
Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work, we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage, and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.