Nasal Drug Delivery in Humans
Nasal Drug Delivery in Humans
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DOI：
10.1159/000321044
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Surber, Christian
中科院分区：
文献类型：
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作者：
Bitter, Christoph;Suter-Zimmermann, Katja;Surber, Christian
鼻腔给药是许多治疗剂局部和全身给药的一个有吸引力的选择。与其他粘膜相比，鼻黏膜更容易接触到。鼻腔给药是非侵入性的，本质上是无痛的，特别适合儿童。在紧急情况下，患者或医生可以很容易地进行应用。鼻腔给药可迅速起到治疗作用(局部或全身)。鼻腔给药可避免药物的胃肠道降解和肝脏首过代谢。药物、车辆和施药装置构成不可分割的三位一体。因此，它的选择对于成功开发有效的鼻腔产品至关重要。本文讨论了鼻腔给药的可行性和潜力。讨论了关于(A)预期用途(治疗方面的考虑)、(B)药物、(C)载体和(D)应用装置(药学方面的考虑)的一系列问题，以期了解它们对鼻用产品开发的影响。讨论了当前和未来的趋势和前景。版权所有(C)2011 S.Karger AG，巴塞尔
Intranasal administration is an attractive option for local and systemic delivery of many therapeutic agents. The nasal mucosa is - compared to other mucosae - easily accessible. Intranasal drug administration is noninvasive, essentially painless and particularly suited for children. Application can be performed easily by patients or by physicians in emergency settings. Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic). Nasal application circumvents gastrointestinal degradation and hepatic first-pass metabolism of the drug. The drug, the vehicle and the application device form an undividable triad. Its selection is therefore essential for the successful development of effective nasal products. This paper discusses the feasibility and potential of intranasal administration. A series of questions regarding (a) the intended use (therapeutic considerations), (b) the drug, (c) the vehicle and (d) the application device (pharmaceutical considerations) are addressed with a view to their impact on the development of products for nasal application. Current and future trends and perspectives are discussed. Copyright (C) 2011 S. Karger AG, Basel