Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting
Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting
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DOI：
10.1667/rr3323.1
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发表时间：
2005-10-01
影响因子：
3.4
通讯作者：
Cucinotta, FA
中科院分区：
文献类型：
--
作者：
George, K;Willingham, V;Cucinotta, FA
在航天飞行后5个月至5年多的不同时间间隔，通过FISH染色体涂染对宇航员血液淋巴细胞中的染色体畸变进行了后续测量，并与飞行前的基线测量进行了比较。对所研究的六名宇航员中的五名宇航员进行的易位个体时间进程分析显示，产量暂时下降，半衰期从10个月到58个月不等。在飞行后5个月的观察期内，第六名航天员的交换量保持不变。这些结果可能表明并发症，使用稳定的像差进行回顾性剂量重建，衰减时间的差异可能反映空间辐射照射风险的个体差异。
Follow-up measurements of chromosome aberrations in the blood lymphocytes of astronauts were performed by FISH chromosome painting at various intervals from 5 months to more than 5 years after space flight and compared to preflight baseline measurements. For five of the six astronauts studied, the analysis of individual time courses for translocations revealed a temporal decline of yields with half-lives ranging from 10 to 58 months. yield of exchanges remained unchanged for the sixth astronaut during an observation period of 5 months after flight. These results may indicate complications, with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure.