Superoxide dismutases in relation to the overall survival of colorectal cancer patients.
Superoxide dismutases in relation to the overall survival of colorectal cancer patients.
复制标题
DOI：
10.1038/bjc.1998.626
复制
发表时间：
1998-10
影响因子：
8.8
通讯作者：
Verspaget HW
中科院分区：
文献类型：
--
作者：
Janssen AM;Bosman CB;Sier CF;Griffioen G;Kubben FJ;Lamers CB;van Krieken JH;van de Velde CJ;Verspaget HW
活性氧代谢物与癌症的发生和促进有关。此外，氧化剂清除剂，例如锰（Mn-SOD）和铜/锌超氧化物歧化酶（Cu/Zn-SOD），被认为有助于结直肠癌的治疗反应。在本研究中，通过与主要临床病理参数的比较，评估了 163 例结直肠癌患者正常粘膜和癌组织中 Mn 和 Cu/Zn-SOD 抗原含量对 5 年总生存率的预后意义。癌组织中Mn-SOD含量显着高于正常粘膜，而Cu/Zn-SOD含量在正常粘膜与癌组织之间无差异。除 Cu/Zn-SOD 和癌的分化等级外，组织的 Mn-SOD 和 Cu/Zn-SOD 含量与评估的临床病理学参数（性别、年龄、定位、分化等级、直径和 Dukes 分期）之间没有明显关联。单变量分析显示，癌组织中高Mn-SOD含量与结直肠癌患者较差的5年总生存率相关。包括所有临床病理学参数的多变量分析表明，该 Mn-SOD 参数与预后无关。正常粘膜的Mn-和Cu/Zn-SOD含量以及癌的Cu/Zn-SOD含量与患者的总生存期无关。总之，本研究表明，对于结直肠癌患者，结直肠癌的 Mn-SOD 含量具有显着的预后价值，且独立于主要临床病理参数（包括 Dukes 分期）。
Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.