Maternal and fetal thyroxine secretion during pregnancy in the sheep.
Maternal and fetal thyroxine secretion during pregnancy in the sheep.
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绵羊怀孕期间母体和胎儿甲状腺素的分泌。
DOI：
10.1210/endo-88-1-47
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发表时间：
1971
期刊：
影响因子：
4.8
通讯作者：
D. Fisher
中科院分区：
文献类型：
--
作者：
J. Dussault;C. Hobel;D. Fisher
将留置的外置股动脉导管放置在胎仔中，将颈静脉导管放置在妊娠100-135天的母羊中。手术后，示踪剂量的125 I-T4和131 I-T4分别注入到母亲和胎儿，并从每个系列的血液标本，为期96小时期间，母亲高氯酸盐管理。制备每份标本的碱洗丁醇提取物，用于双同位素计数;根据这些数据，确定母体和胎儿中同位素的分布容积和血浆消失。总T4的测定采用Murphy和Pattee的方法。未检测到胎儿或母体同位素（如T4）通过胎盘。母体和胎仔中T4的平均t1/2值分别为1.1天和0.7天，平均T4分泌率分别为367和103 μg/天或5.5和41 μg /kg /天。这些数据表明：a）自主的胎儿垂体甲状腺系统和B）妊娠最后三个月胎儿T4分泌率高。（远藤...
Indwelling, exteriorized femoral artery catheters were placed in the fetuses and jugular vein catheters in ewes of 100–135 days of gestation. Postoperatively, tracer doses of 125I-T4 and 131I-T4 were injected into the mother and fetus, respectively, and serial blood specimens were drawn from each for a period of 96 hr during maternal perchlorate administration. Alkali- washed butanol extracts were prepared of each specimen for dual isotope counting; from these data the volume of distribution and plasma disappearance of isotope were determined in the mother and fetus. Measurements of total T4 were determined by the method of Murphy and Pattee. No placental passage of fetal or maternal isotopes as T4 was detected. The mean t½, values for T4 in the mother and fetus were 1.1 and 0.7 days and mean T4 secretion rates 367 and 103 μg/day or 5.5 and 41 μg /kg /day. The data indicate a) an autonomous fetal pituitarythyroid system and b) a high rate of fetal T4 secretion during the last trimester of gestation. (Endo...