Cardioprotection by hormetic responses to aldehyde.
Cardioprotection by hormetic responses to aldehyde.
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通过对醛的毒物兴奋反应来保护心脏。
DOI：
10.1253/circj.cj-10-0716
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
M. Sano
中科院分区：
文献类型：
--
作者：
M. Sano
每个人在日常生活中都会遇到各种各样的压力源（压力的原因），如心理压力、精神波动和身体负担。人们普遍认为，最高水平的感知压力与心血管疾病的早期发病有关。相反，适当的（轻度到中度）压力源，如体育活动，已被证明可以促进健康。这种治疗在低剂量下有益但在高剂量下有害的双向剂量-反应关系被称为“激效效应”。在毒理学、药理学、辐射生物学和医学等领域，低水平暴露于各种物质的生物效应的重要性引起了相当大的关注。了解生物系统如何应对低水平的压力及其对社会的影响是非常重要的。醛是脂质过氧化的主要终产物，与氧化应激相关疾病的发病机制有关。除了与氧化应激相关的致病作用外，亚致死水平的醛与信号系统相互作用，上调基因表达，以抵消应激源的挑战，并重新建立体内平衡。本文就醛致热反应的最新发现及其在心脏保护中的临床意义进行综述。
Everyone encounters various stressors (causes of stress), such as psychological pressure, mental fluctuations, and physical burdens, in their everyday life. It is well accepted that the highest levels of perceived stress correlate with early onset of cardiovascular disease. Conversely, appropriate (mild to moderate) stressors, such as physical activity, have been shown to promote health. This bidirectional dose - response relationship of treatments that are beneficial at low levels but noxious at higher levels is referred to as "hormesis". In the fields of toxicology, pharmacology, radiation biology, and medicine, the significance of the biological effects of low-level exposure to various agents has attracted considerable attention. It is very important to understand how biological systems respond to low levels of stress and their implications within society. Aldehydes, the major endproducts of lipid peroxidation, have been implicated in the pathogenesis of oxidative stress-associated diseases. In addition to the pathogenic effect associated with oxidative stress, sublethal levels of aldehydes interact with signaling systems to upregulate the expression of genes to counteract the stressor challenge and to re-establish homeostasis. The present review article discusses current discoveries regarding the hormetic response to aldehyde and its clinical significance in cardioprotection.
影响因子：
5
作者：
Churchill, Eric N.;Disatnik, Marie-Helene;Mochly-Rosen, Daria
通讯作者：
Mochly-Rosen, Daria
影响因子：
1.7
作者：
Yusong Yang;Rajendra K. Sharma;Abha Sharma;S. Awasthi;Y. Awasthi
通讯作者：
Yusong Yang;Rajendra K. Sharma;Abha Sharma;S. Awasthi;Y. Awasthi
影响因子：
3.9
作者：
Wek, RC;Jiang, HY;Anthony, TG
通讯作者：
Anthony, TG